MOUSE ANTI SYK

• Catalog number
  MBS212754
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [SYK]
• Other_names
  [tyrosine-protein kinase SYK isoform Syk(S); Tyrosine-protein kinase SYK; tyrosine-protein kinase SYK; spleen tyrosine kinase; Spleen tyrosine kinase; p72-Syk]
• Products_gene_name
  [SYK]
• Other_gene_names
  [SYK; SYK; p72-Syk]
• Clonality
  Monoclonal
• Clone
  [SYK-01]
• Reactivity
  Mouse, Rat
• Specificity
  This item recognizes protein tyrosine kinase p72syk (syk), a 72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
• Form
  Purified Purified IgG - liquid
• Concentration
  Ig concentration 1.0 mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Shelf Life: 18 months from date of despatch.
• Tested_application
  Immunoprecipitation (IP), Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  SYK  
• Gene symbol
  SYK
• Short name
  MOUSE ANTI SYK
• Technique
  Mouse, anti, antibody to, mouses
• Host
  Mouse
• Isotype
  IgG1
• Species
  Mouse, Mouses
• Alternative name
  MOUSE antibody to spleen tyrosine kinase
• Alternative technique
  murine, antibodies
• Alternative to gene target
  spleen tyrosine kinase, p72-Syk, SYK and IDBG-75571 and ENSG00000165025 and 6850, transferase activity, Plasma membranes, Syk and IDBG-152695 and ENSMUSG00000021457 and 20963, SYK and IDBG-637026 and ENSBTAG00000004767 and 515515

Gene info

• Identity
  HGNC:11491
• Gene
  SYK
• Long gene name
  spleen associated tyrosine kinase
• Synonyms gene name
  • spleen tyrosine kinase
• GenBank acession
  • L28824
• Locus
  9q22.2
• Discovery year
  1994-12-13
• Entrez gene record
  6850
• Pubmed identfication
  • 8082894
  • 1423621
• Classification
  • Syk family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000020200

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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