MOUSE ANTI HUMAN SIGLEC-10

• Catalog number
  MBS224495
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [SIGLEC-10]
• Other_names
  [sialic acid-binding Ig-like lectin 10 isoform 2; Sialic acid-binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; siglec-like gene 2; siglec-like protein 2; sialic acid binding Ig-like lectin 10; Siglec-like protein 2]
• Products_gene_name
  [SIGLEC-10]
• Other_gene_names
  [SIGLEC10; SIGLEC10; SLG2; PRO940; SIGLEC-10; SLG2; Siglec-10]
• Clonality
  Monoclonal
• Clone
  [5G6]
• Specificity
  Clone 5G6 specifically recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see Kive, E. et al. for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0 mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Flow cytometry (FC/FACS)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  SIGLEC-10  
• Gene symbol
  SIGLEC10, SIGLEC10-AS1, SIGLEC12, PIRC49, CD22, SNORD115-10, SNORD116-10, IGHV3OR16-10
• Short name
  MOUSE ANTI SIGLEC-10
• Technique
  anti human, Mouse, anti, antibody to, anti human antibodies, mouses
• Host
  Mouse
• Isotype
  IgG1
• Species
  Human, Humans, Mouses
• Alternative name
  MOUSE antibody to H. sapiens SIGLEC-10
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:15620
• Gene
  SIGLEC10
• Long gene name
  sialic acid binding Ig like lectin 10
• Synonyms gene name
  • sialic acid binding Ig-like lectin 10
• Synonyms
  • SIGLEC-10
  • SLG2
  • PRO940
  • MGC126774
• Synonyms name
  • sialic acid binding Ig-like lectin 10 Ig-like lectin 7
  • siglec-like gene 2
• GenBank acession
  • AF310233
• Locus
  19q13.41
• Discovery year
  2001-06-29
• Entrez gene record
  89790
• Pubmed identfication
  • 11284738
• RefSeq identity
  • NM_033130
• Classification
  • C2-set domain containing
  • Sialic acid binding Ig like lectins
  • V-set domain containing
• VEGA ID
  OTTHUMG00000165521

Gene info

• Identity
  HGNC:40719
• Gene
  SIGLEC10-AS1
• Long gene name
  SIGLEC10 antisense RNA 1
• Locus
  19q13.41
• Discovery year
  2020-03-20
• Entrez gene record
  100129083
• RefSeq identity
  • NR_164124
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:15482
• Gene
  SIGLEC12
• Long gene name
  sialic acid binding Ig like lectin 12
• Synonyms gene
  • SIGLECL1
• Synonyms gene name
  • SIGLEC-like 1
  • sialic acid binding Ig-like lectin 12
  • sialic acid binding Ig-like lectin 12 (gene/pseudogene)
  • sialic acid binding Ig like lectin 12 (gene/pseudogene)
• Synonyms
  • SLG
  • S2V
  • Siglec-XII
  • Siglec-12
  • Siglec-L1
• GenBank acession
  • AF282256
• Locus
  19q13.41
• Discovery year
  2001-08-28
• Entrez gene record
  89858
• Pubmed identfication
  • 11409877
  • 11328818
  • 21555517
• RefSeq identity
  • NM_053003
• Classification
  • C2-set domain containing
  • I-set domain containing
  • Sialic acid binding Ig like lectins
  • V-set domain containing
• VEGA ID
  OTTHUMG00000165524

Gene info

• Identity
  HGNC:37553
• Gene
  PIRC49
• Long gene name
  piwi-interacting RNA cluster 49
• Locus
  10
• Discovery year
  2009-11-05
• Entrez gene record
  100313929
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:1643
• Gene
  CD22
• Long gene name
  CD22 molecule
• Synonyms gene name
  • CD22 antigen
• Synonyms
  • SIGLEC-2
  • SIGLEC2
• Synonyms name
  • sialic acid binding Ig-like lectin 2
• GenBank acession
  • X52785
• Locus
  19q13.12
• Discovery year
  1991-06-06
• Entrez gene record
  933
• Pubmed identfication
  • 8496602
  • 1691828
• RefSeq identity
  • NM_001771
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • C2-set domain containing
  • Sialic acid binding Ig like lectins
• VEGA ID
  OTTHUMG00000183298

Gene info

• Identity
  HGNC:33029
• Gene
  SNORD115-10
• Long gene name
  small nucleolar RNA, C/D box 115-10
• Synonyms
  • HBII-52-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033447
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003302.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33076
• Gene
  SNORD116-10
• Long gene name
  small nucleolar RNA, C/D box 116-10
• Synonyms
  • HBII-85-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033422
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003325
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5634
• Gene
  IGHV3OR16-10
• Long gene name
  immunoglobulin heavy variable 3/OR16-10 (non-functional)
• Synonyms gene name
  • immunoglobulin heavy variable 3/OR16-10
• Synonyms
  • IGHV3/OR16-10
• GenBank acession
  • Z29607
• Locus
  16p11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28306
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000176446

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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