Mouse Anti-Human Fas Ligand-UNLB

• Catalog number
  MBS670167
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [Fas Ligand (CD178)]
• Products_name_syn
  [Mouse Anti-Human Fas Ligand - Purified, Unlabeled Antibody; Mouse anti-Human Fas Ligand (CD178)]
• Other_names
  [Fas ligand (TNF superfamily, member 6); Tumor necrosis factor ligand superfamily member 6; tumor necrosis factor ligand superfamily member 6; APTL; CD95 ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand; apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6); Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand]
• Other_gene_names
  [FASLG; FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; APT1LG1; CD95L; FASL; TNFSF6]
• Clonality
  Monoclonal
• Clone
  [SB93a1]
• Reactivity
  Human
• Specificity
  Reacts with native and recombinant human Fas Ligand1 Fas Ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells2,3. Moreover, studies indicate that Fas Ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death4. Fas Ligand initiates apoptosis by binding to its receptor (CD95) on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase- 85. The SB93a monoclonal antibody detects a band at ~40 kD, corresponding to the transmembrane (insoluble) form of Fas Ligand.
• Form
  Purified (UNLB) Antibody
• Storage_stability
  The purified (UNLB) antibody is supplied as 0.1mg purified immunoglobulin in 0.2mL of 100 mM borate buffered saline, pH 8.0; store at 2-8 degree C. The fluorescein (FITC) conjugate is supplied as 0.1mg in 0.2mL of PBS/NaN3. Store at 2- 8 degree C. Reagents are stable for the period shown on the label if stored as directed.
• Tested_application
  Flow Cytometry; Immunoprecipitation; Western Blot
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Test
  MyBioSource supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Latin name
  Mus musculus

• Gene target
  Fas   Ligand-UNLB  
• Short name
  Mouse Anti- Fas Ligand-UNLB
• Technique
  anti-Human, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, mouses
• Host
  Mouse
• Isotype
  Mouse IgG2b
• Species
  Human, Humans, Mouses
• Alternative name
  Mouse Antibody toHuman Fas (tumor necrosis factor receptor superfamily, member 6) Ligand-UNLB
• Alternative technique
  murine, antibodies
• Alternative to gene target
  Fas (TNF receptor superfamily, member 6), ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-81669 and ENSG00000026103 and 355, identical protein binding, nuclei, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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