MOUSE ANTI HUMAN CLUSTERIN
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Catalog numberMBS212917
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PricePlease ask
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Size5x0.1 mg
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Products_typeAntibody
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Products_short_name[CLUSTERIN]
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Other_names[clusterin preproprotein; Clusterin; clusterin; aging-associated protein 4; apolipoprotein J; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; sulfated glycoprotein 2; testosterone-repressed prostate message 2; clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate message 2; TRPM-2]
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Other_gene_names[CLU; CLU; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; APOJ; CLI; KUB1; Apo-J; CLI; TRPM-2]
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ClonalityMonoclonal
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Clone[3R3/2]
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SpecificityThis item recognises clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
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FormPurified Purified IgG - liquid
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ConcentrationIgG concentration 1.0 mg/ml
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Storage_stabilityStore at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
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Tested_applicationImmunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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Gene target
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Gene symbolCLUL1, CLU, CLUAP1
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Short nameMOUSE ANTI CLUSTERIN
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Techniqueanti human, Mouse, anti, antibody to, anti human antibodies, mouses
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HostMouse
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IsotypeIgG1
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SpeciesHuman, Humans, Mouses
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Alternative nameMOUSE antibody to H. sapiens CLUSTERIN
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Alternative techniquemurine, antibodies
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Gene info
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Identity
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Gene
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Long gene nameclusterin like 1
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Synonyms gene name
- clusterin-like 1 (retinal)
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-05-30
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameclusterin
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Synonyms gene
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Synonyms gene name
- clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-07-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Complement system regulators and receptors
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameclusterin associated protein 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-09-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- IFT-B2 complex
- Cilia and flagella associated
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data