MOUSE ANTI HUMAN CLUSTERIN

• Catalog number
  MBS212917
• Price
  Please ask
• Size
  0.1 mg

• Products_type
  Antibody
• Products_short_name
  [CLUSTERIN]
• Other_names
  [clusterin preproprotein; Clusterin; clusterin; aging-associated protein 4; apolipoprotein J; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; sulfated glycoprotein 2; testosterone-repressed prostate message 2; clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate message 2; TRPM-2]
• Other_gene_names
  [CLU; CLU; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; APOJ; CLI; KUB1; Apo-J; CLI; TRPM-2]
• Clonality
  Monoclonal
• Clone
  [3R3/2]
• Specificity
  This item recognises clusterin, an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0 mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  CLUSTERIN  
• Gene symbol
  CLUL1, CLU, CLUAP1
• Short name
  MOUSE ANTI CLUSTERIN
• Technique
  anti human, Mouse, anti, antibody to, anti human antibodies, mouses
• Host
  Mouse
• Isotype
  IgG1
• Species
  Human, Humans, Mouses
• Alternative name
  MOUSE antibody to H. sapiens CLUSTERIN
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:2096
• Gene
  CLUL1
• Long gene name
  clusterin like 1
• Synonyms gene name
  • clusterin-like 1 (retinal)
• Synonyms name
  • retinal clusterin-like protein
• GenBank acession
  • D63813
• Locus
  18p11.32
• Discovery year
  2000-05-30
• Entrez gene record
  27098
• Pubmed identfication
  • 10675623
  • 14507903
• VEGA ID
  OTTHUMG00000178252

Gene info

• Identity
  HGNC:2095
• Gene
  CLU
• Long gene name
  clusterin
• Synonyms gene
  • CLI
  • APOJ
• Synonyms gene name
  • clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
• Synonyms
  • SGP-2
  • SP-40
  • TRPM-2
  • KUB1
  • CLU1
  • CLU2
• Synonyms name
  • complement lysis inhibitor
  • sulfated glycoprotein 2
  • testosterone-repressed prostate message 2
  • apolipoprotein J
• GenBank acession
  • M64722
• Locus
  8p21.1
• Discovery year
  1990-07-26
• Entrez gene record
  1191
• Pubmed identfication
  • 1585460
• RefSeq identity
  • NM_001831
• Classification
  • Complement system regulators and receptors
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000102114

Gene info

• Identity
  HGNC:19009
• Gene
  CLUAP1
• Long gene name
  clusterin associated protein 1
• Synonyms
  • FLJ13297
  • KIAA0643
  • FAP22
  • CFAP22
  • IFT38
• Synonyms name
  • flagellar associated protein 22, qilin-like protein, homolog (Chlamydomonas)
  • cilia and flagella associated protein 22
• GenBank acession
  • BC017070
• Locus
  16p13.3
• Discovery year
  2004-09-16
• Entrez gene record
  23059
• Pubmed identfication
  • 15480429
  • 19253336
• RefSeq identity
  • NM_024793
• Classification
  • IFT-B2 complex
  • Cilia and flagella associated
• VEGA ID
  OTTHUMG00000177581

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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