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Products_type
Active Protein
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Products_short_name
[Heregulin beta 2]
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Products_name_syn
[Heregulin beta 2, Recombinant, Human (NRG1, Pro-neuregulin-1, Membrane-bound Isoform, Pro-NRG1, Neuregulin-1, Acetylcholine Receptor-inducing Activity, ARIA, Breast Cancer Cell Differentiation Factor p45, Glial Growth Factor, Heregulin, HRG, Neu Different]
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Purity
Highly Purified~95% (RP-HPLC and SDS-PAGE)
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Form
Supplied as a lyophilized powder from 20mM PB, pH 7.0, 0.5%HSA, 2% mannitol. Reconstitute with sterile 18Mo-cm H2O to 100ug/ml.
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Storage_stability
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Description
For cells, cell lines and tissues in culture till half confluency. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae. , The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
NRG1, NRG1-IT1, NRG1-IT3, HRG-AS1, ECSCR, HRG
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Short name
Heregulin beta 2, Recombinant, (NRG1, Pro-neuregulin-1, -bound Isoform, Pro-NRG1, Neuregulin-1, Acetylcholine Receptor- Activity, ARIA, Breast Cancer Differentiation Factor p45, Glial Growth Factor, Heregulin, HRG, Neu Different
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Heregulin b 2, Rec., H. sapiens (neuregulin 1, L-proline-neuregulin-1, Membrane-bound Isoform, L-proline-neuregulin 1, Neuregulin-1, Acetylcholine Receptor-inducing Activity, ARIA, Breast Cancer cellular Differentiation Factor p45, Glial Growth Factor, Heregulin, histidine-rich glycoprotein, Neu Different
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Alternative technique
rec
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Alternative to gene target
neuregulin 1, ARIA and GGF and GGF2 and HGL and HRG and HRG1 and HRGA and MST131 and MSTP131 and NDF and NRG1-IT2 and SMDF, NRG1 and IDBG-16182 and ENSG00000157168 and 3084, ErbB-3 class receptor binding, nuclei, Nrg1 and IDBG-146861 and ENSMUSG00000062991 and 211323, NRG1 and IDBG-628923 and ENSBTAG00000004150 and 281361
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Tissue
breast, cell
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Disease
cancer
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