Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz-Type I, SPINT1)

• Catalog number
  MBS602273
• Price
  Please ask
• Size
  5x0.5 mg

• Products_type
  Antibody
• Products_short_name
  [Hepatocyte Growth Factor Activator Inhibitor 1]
• Products_name_syn
  [Anti -Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz-Type I, SPINT1)]
• Other_names
  [hepatocyte growth factor activator inhibitor 1B; Kunitz-type protease inhibitor 1; kunitz-type protease inhibitor 1; HAI-1; serine protease inhibitor, Kunitz type 1; hepatocyte growth factor activator inhibitor type 1; serine peptidase inhibitor, Kunitz type 1; Hepatocyte growth factor activator inhibitor type 1]
• Other_gene_names
  [SPINT1; SPINT1; HAI; HAI1; MANSC2; HAI1; HAI-1]
• Clonality
  Monoclonal
• Clone
  [7H50]
• Reactivity
  Human
• Specificity
  Recognizes human HAI-1.
• Purity
  Affinity Purified Purified by Protein G affinity chromatography.
• Form
  Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
• Storage_stability
  Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  ELISA (EL/EIA)
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Serine protease, D- or L-serine arginine rich enzyme of serine threonine kinase with serine that is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+ 3 form under biological conditions), a carboxyl group. It is non-essential in humans, meaning the body can synthesize it.

• Gene target
  Hepatocyte   Growth   Factor   Activator   Inhibitor   HAI-1   Serine   Protease   Inhibitor   Kunitz   SPINT1  
• Gene symbol
  SPINT1, SPINT2, SPINT1-AS1, ST14, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1
• Short name
  Hepatocyte Growth Factor Activator Inhibitor 1 (HAI-1, Serine Protease Inhibitor Kunitz- I, SPINT1)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  Hepatocyte Growth Factor Activator suppressor 1 (HAI-1, Serine Protease suppressor Kunitz-classification I, SPINT1)

Gene info

• Identity
  HGNC:11246
• Gene
  SPINT1
• Long gene name
  serine peptidase inhibitor, Kunitz type 1
• Synonyms gene name
  • serine protease inhibitor, Kunitz type 1
• Synonyms
  • HAI
  • MANSC2
• Locus
  15q15.1
• Discovery year
  1988-07-18
• Entrez gene record
  6692
• RefSeq identity
  • NM_003710
• VEGA ID
  OTTHUMG00000130068

Gene info

• Identity
  HGNC:11247
• Gene
  SPINT2
• Long gene name
  serine peptidase inhibitor, Kunitz type 2
• Synonyms gene name
  • serine protease inhibitor, Kunitz type, 2
• Synonyms
  • Kop
  • HAI-2
• Synonyms name
  • placental bikunin
• GenBank acession
  • U78095
• Locus
  19q13.2
• Discovery year
  1999-07-23
• Entrez gene record
  10653
• Pubmed identfication
  • 9115294
  • 9346890
• VEGA ID
  OTTHUMG00000181891

Gene info

• Identity
  HGNC:53162
• Gene
  SPINT1-AS1
• Long gene name
  SPINT1 antisense RNA 1
• Synonyms
  • RP11-532F12.5
• Locus
  15q15.1
• Discovery year
  2017-03-03
• Entrez gene record
  102724362
• Pubmed identfication
  • 28225791
• RefSeq identity
  • NR_146466
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:11344
• Gene
  ST14
• Long gene name
  ST14 transmembrane serine protease matriptase
• Synonyms gene
  • PRSS14
• Synonyms gene name
  • suppression of tumorigenicity 14 (colon carcinoma)
  • suppression of tumorigenicity 14
• Synonyms
  • SNC19
  • HAI
  • MT-SP1
  • TMPRSS14
  • CAP3
• Synonyms name
  • epithin
  • matriptase
  • channel–activating protein 3
• GenBank acession
  • AF118224
• Locus
  11q24.3
• Discovery year
  1998-05-05
• Entrez gene record
  6768
• Pubmed identfication
  • 9925927
  • 10373424
• Classification
  • Type II transmembrane serine proteases
• VEGA ID
  OTTHUMG00000165768

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:5760
• Gene
  IGKV1OR2-1
• Long gene name
  immunoglobulin kappa variable 1/OR2-1 (pseudogene)
• Synonyms gene
  • IGKVPZ1
  • IGKV1OR-1
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR-1
  • immunoglobulin kappa variable 1/OR-1 pseudogene
  • immunoglobulin kappa variable 1/OR-1 (pseudogene)
• Synonyms
  • IGKV1/OR-1
  • IGKV1/OR2-1
• GenBank acession
  • Z12367
• Locus
  2p11.1
• Discovery year
  2000-04-18
• Entrez gene record
  3531
• Pubmed identfication
  • 2853098
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000155081

Gene info

• Identity
  HGNC:35281
• Gene
  MIR1289-1
• Long gene name
  microRNA 1289-1
• Synonyms gene
  • MIRN1289-1
• Synonyms
  • hsa-mir-1289-1
• Locus
  20q11.22
• Discovery year
  2008-11-03
• Entrez gene record
  100302125
• RefSeq identity
  • NR_031620
• Classification
  • MicroRNA MIR1289 family

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