GITR / Tnfrsf18 (mouse) Rat Monoclonal Antibody
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Products_type
Antibody
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Products_short_name
[GITR / Tnfrsf18]
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Products_name_syn
[Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18]
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Other_names
[tumor necrosis factor receptor superfamily member 18 isoform 1; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; Glucocorticoid-induced TNFR-related protein; CD_antigen: CD357]
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Products_gene_name
[Tnfrsf18]
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Other_gene_names
[Tnfrsf18; Tnfrsf18; AITR; Gitr; Gitr]
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Clonality
Monoclonal
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Clone
[DTA-1]
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Reactivity
Mouse
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Specificity
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAP's and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
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Properties
If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes. Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus, Rattus norvegicus
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French translation
anticorps
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Gene target
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Gene symbol
TNFRSF18
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Short name
GITR / Tnfrsf18 (mouse) Monoclonal Antibody
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Technique
Antibody, Mouse, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies, mouses
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Host
Rat
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Isotype
IgG2b, lambda
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Species
Rat, Mouses, Rats
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Alternative name
GITR / tumor necrosis factor receptor superfamily, member 18 (mouse) Rat monoclonal (antibody to-)
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Alternative technique
antibodies, murine
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Alternative to gene target
tumor necrosis factor receptor superfamily, member 18, AITR and CD357 and GITR and GITR-D, TNFRSF18 and IDBG-84584 and ENSG00000186891 and 8784, protein binding, Extracellular, Tnfrsf18 and IDBG-208288 and ENSMUSG00000041954 and 21936, TNFRSF18 and IDBG-635325 and ENSBTAG00000015632 and 516256
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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