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Products_type
Antibody
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Products_short_name
[Epidermal Growth Factor Receptor Receptor]
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Products_name_syn
[Anti -Epidermal Growth Factor Receptor, phosphorylated Receptor (Tyr1068) (EGFR, Epidermal Growth Factor Receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor precursor, ERBB, ERBB1, HER1, mENA, PIG61, Rece]
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Other_names
[epidermal growth factor receptor; Epidermal growth factor receptor; epidermal growth factor receptor; OTTHUMP00000159661; OTTHUMP00000159662; OTTHUMP00000159663; OTTHUMP00000209210; OTTHUMP00000209211; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1]
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Other_gene_names
[EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; ERBB1]
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Clonality
Monoclonal
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Clone
[3i13]
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Reactivity
Human, Monkey, Rat
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Specificity
Recognizes overexpressed levels of human EGF receptor only when phosphorylated at Tyr1068. Does not recognize other sites of tyrosine phosphorylation on EGF receptor, nor does it crossreact with other tyrosine-phosphorylated proteins. Species crossreactivity: rat and monkey.
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Purity
Ascites Ascites
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Form
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA,
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Storage_stability
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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Tested_application
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Precursor cell, also called a blast cell or simply blast, is a type of partially differentiated, usually unipotent cell that has lost most or all of the stem cell multipotency. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
EGFR, EGFR-AS1, EGILA, RHBDF1
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Short name
Epidermal Growth Factor Receptor, phosphorylated Receptor (Tyr1068) (EGFR, Epidermal Growth Factor Receptor (erythroblastic leukemia (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor , ERBB, ERBB1, HER1, mENA, PIG61, Rece
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Host
Mouse
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Isotype
IgG1
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Alternative name
Epidermal Growth Factor Receptor, phosphorylated Receptor (Tyr1068) (epidermal growth factor receptor, Epidermal Growth Factor Receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), Epidermal growth factor receptor precursor, ERBB, ERBB1, HER1, mENA, PIG61, Rece
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Alternative to gene target
epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217
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Virus
leukemia
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