CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
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Products_type
Antibody
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Products_short_name
[CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)]
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Products_name_syn
[ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR]
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Other_names
[cystic fibrosis transmembrane conductance regulator; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49]
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Products_gene_name
[CFTR]
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Other_gene_names
[CFTR; CFTR; CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1; ABCC7; CFTR]
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Clonality
Monoclonal
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Clone
[CFTR/1775R]
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Reactivity
Human. Others not known.
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Specificity
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3', 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
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Form
200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
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Gene target
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Gene symbol
CFTR, CFTR-AS1
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Short name
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
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Host
Rabbit
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Isotype
IgG
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Alternative name
cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C, member 7) (Cystic Fibrosis Transmembrane Conductance Regulator)
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Alternative to gene target
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), ABC35 and ABCC7 and CF and CFTR/MRP and dJ760C5.1 and MRP7 and TNR-CFTR, CFTR and IDBG-37713 and ENSG00000001626 and 1080, ATPase activity, Cell surfaces, Cftr and IDBG-129229 and ENSMUSG00000041301 and 12638, CFTR and IDBG-632747 and ENSBTAG00000006589 and 281067
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Gene info
Gene info
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Identity
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Gene
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Long gene name
CFTR antisense RNA 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
2017-07-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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