CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)

• Catalog number
  MBS439857
• Price
  Please ask
• Size
  5x0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)]
• Products_name_syn
  [ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR]
• Other_names
  [cystic fibrosis transmembrane conductance regulator; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49]
• Products_gene_name
  [CFTR]
• Other_gene_names
  [CFTR; CFTR; CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1; ABCC7; CFTR]
• Clonality
  Monoclonal
• Clone
  [rCFTR/1342]
• Reactivity
  Human, Mouse. Others not known.
• Specificity
  Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3', 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

• Gene target
  CFTR   Cystic   Fibrosis   Transmembrane   Conductance   Regulator  
• Gene symbol
  CFTR, CFTR-AS1
• Short name
  CFTR (Cystic Fibrosis Transmembrane Conductance Regulator)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C, member 7) (Cystic Fibrosis Transmembrane Conductance Regulator)
• Alternative to gene target
  cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), ABC35 and ABCC7 and CF and CFTR/MRP and dJ760C5.1 and MRP7 and TNR-CFTR, CFTR and IDBG-37713 and ENSG00000001626 and 1080, ATPase activity, Cell surfaces, Cftr and IDBG-129229 and ENSMUSG00000041301 and 12638, CFTR and IDBG-632747 and ENSBTAG00000006589 and 281067

Gene info

• Identity
  HGNC:1884
• Gene
  CFTR
• Long gene name
  CF transmembrane conductance regulator
• Synonyms gene
  • CF
  • ABCC7
• Synonyms gene name
  • cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
• Synonyms
  • MRP7
  • ABC35
  • TNR-CFTR
  • dJ760C5.1
  • CFTR/MRP
• Synonyms name
  • ATP-binding cassette sub-family C, member 7
• GenBank acession
  • M28668
• Locus
  7q31.2
• Discovery year
  1986-01-01
• Entrez gene record
  1080
• Pubmed identfication
  • 2772657
• RefSeq identity
  • NM_000492
• Classification
  • ATP binding cassette subfamily C
  • Chloride channels, ATP-gated CFTR
• VEGA ID
  OTTHUMG00000023076
• Locus Specific Databases
  • Cystic Fibrosis
  • LRG_663

Gene info

• Identity
  HGNC:40144
• Gene
  CFTR-AS1
• Long gene name
  CFTR antisense RNA 1
• Synonyms
  • BGas
• GenBank acession
  • BG213071
• Locus
  7q31.2
• Discovery year
  2017-07-26
• Entrez gene record
  111082987
• Pubmed identfication
  • 27434588
• RefSeq identity
  • NR_149084
• Classification
  • Antisense RNAs

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