CD34

• Catalog number
  MBS438348
• Price
  Please ask
• Size
  0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [CD34]
• Products_name_syn
  [Hematopoietic Progenitor Cell Antigen; HPCA1; Mucosialin]
• Other_names
  [hematopoietic progenitor cell antigen CD34 isoform a; Hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell antigen CD34; CD34 antigen; CD34 molecule; CD_antigen: CD34]
• Products_gene_name
  [CD34]
• Other_gene_names
  [CD34; CD34]
• Clonality
  Monoclonal
• Clone
  [QBEnd/10]
• Reactivity
  Human, Cynomolgus Monkey, Rhesus Monkey. Does not react with rat, sheep, cow and dog.
• Specificity
  This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but with a lower specificity.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
• Storage_stability
  Store at 2 to 8 degree C. Antibody is stable for 24 months.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
• Properties
  Stem cell or hematopoietic marker. The most used affinity clone is QBEND10. We compare the affinity to this clone.

• Gene target
  CD34  
• Gene symbol
  CD34
• Short name
  CD34
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  CD34 molecule
• Alternative to gene target
  CD34 molecule, CD34 and IDBG-106399 and ENSG00000174059 and 947, sulfate binding, Extracellular, Cd34 and IDBG-209317 and ENSMUSG00000016494 and 12490, CD34 and IDBG-638449 and ENSBTAG00000010562 and 281051

Gene info

• Identity
  HGNC:1662
• Gene
  CD34
• Long gene name
  CD34 molecule
• Synonyms gene name
  • CD34 antigen
• GenBank acession
  • M81104
• Locus
  1q32.2
• Discovery year
  1990-09-10
• Entrez gene record
  947
• Pubmed identfication
  • 1370171
  • 1374051
• RefSeq identity
  • NM_001773
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000036565

MeSH Data

• Name
  Bone Marrow Examination
• Concept
  Scope note: Removal of bone marrow and evaluation of its histologic picture.
• Tree numbers
  • E01.370.225.625.135
  • E05.200.625.135
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

Similar products