CD34
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Catalog numberMBS438123
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PricePlease ask
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Size0.5 mL
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Products_typeAntibody
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Products_short_name[CD34]
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Products_name_syn[Hematopoietic Progenitor Cell Antigen; HPCA1; Mucosialin]
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Other_names[hematopoietic progenitor cell antigen CD34 isoform a; Hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell antigen CD34; CD34 antigen; CD34 molecule; CD_antigen: CD34]
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Products_gene_name[CD34]
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Other_gene_names[CD34; CD34]
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ClonalityMonoclonal
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Clone[ICO-115]
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ReactivityHuman and Rat. Others not known.
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SpecificityThis antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but shows low specificity.
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PurityPurified Ab conjugated to PE
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FormAntibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM pbs with 0.05% BSA and 0.05% azide.
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Storage_stabilityStore at 2 to 8°C. Antibody is stable for 24 months.
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Tested_applicationFlow Cytometry (FC/FACS)
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PropertiesStem cell or hematopoietic marker. The most used affinity clone is QBEND10. We compare the affinity to this clone.
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Gene target
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Gene symbolCD34
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Short nameCD34
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HostMouse
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IsotypeIgG1, kappa
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Alternative nameCD34 molecule
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Alternative to gene targetCD34 molecule, CD34 and IDBG-106399 and ENSG00000174059 and 947, sulfate binding, Extracellular, Cd34 and IDBG-209317 and ENSMUSG00000016494 and 12490, CD34 and IDBG-638449 and ENSBTAG00000010562 and 281051
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Gene info
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Identity
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Gene
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Long gene nameCD34 molecule
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Synonyms gene name
- CD34 antigen
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GenBank acession
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Locus
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Discovery year1990-09-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
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Tree numbers
- E01.370.225.500.383.910
- E01.370.225.500.388.930
- E05.200.500.383.910
- E05.200.500.388.930
- E05.242.383.910
- E05.242.417.500
- E05.337.550.200.800
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data