Caspase 1, beta (Interleukin-1 Beta Converting Enzyme, ICE) Substrate IV [Ac-Tyr-Val-Ala-Asp-pNA]

• Catalog number
  MBS657955
• Price
  Please ask
• Size
  1 mg

• Products_type
  Peptide
• Products_short_name
  [Caspase 1, beta]
• Other_names
  [caspase-1; Caspase-1; caspase-1; p45; CASP-1; IL-1BC; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1, beta, convertase; Interleukin 1beta converting enzyme; interleukin-1 beta-converting enzyme; caspase 1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45]
• Other_gene_names
  [Casp1; Casp1; Ice; Il1bc; Il1bc; Il1bce; CASP-1; IL-1BC; ICE]
• Purity
  Highly Purified~95%. Purified by HPLC.
• Form
  Supplied as a lyophilized powder.
• Storage_stability
  Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer._x000B_ _x000B_
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.

• Gene target
  Caspase   beta   Interleukin-1   Beta   Converting   ICE   Substrate   [Ac-Tyr-Val-Ala-Asp-pNA]  
• Gene symbol
  CASP1, CASP5, CES2, CARD18, CARD16, CASP4, CASP9, CASP7
• Short name
  Caspase 1, beta (Interleukin-1 Beta Converting Enzyme, ICE) Substrate IV [Ac-Tyr-Val-Ala-Asp-pNA]
• Technique
  Enzyme, enzymes
• Host
  Synthetic peptide
• Alternative name
  caspase 1, b (Interleukin-1 b Converting Enzyme, ICE) Substrate IV [Ac-L-tyrosine-L-valine-alanine-L-aspartic acid-pNA]
• Alternative technique
  enzymes

Gene info

• Identity
  HGNC:1499
• Gene
  CASP1
• Long gene name
  caspase 1
• Synonyms gene
  • IL1BC
• Synonyms gene name
  • caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase
• Synonyms
  • ICE
• Synonyms name
  • caspase-1
  • interleukin 1, beta, convertase
• GenBank acession
  • U13697
• Locus
  11q22.3
• Discovery year
  1992-05-07
• Entrez gene record
  834
• Pubmed identfication
  • 1373520
  • 9250871
• RefSeq identity
  • NM_033292
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000048072

Gene info

• Identity
  HGNC:1506
• Gene
  CASP5
• Long gene name
  caspase 5
• Synonyms gene name
  • caspase 5, apoptosis-related cysteine protease
  • caspase 5, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)III
• Locus
  11q22.3
• Discovery year
  1996-09-13
• Entrez gene record
  838
• Pubmed identfication
  • 7797592
  • 9250871
• RefSeq identity
  • NM_004347
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000048073

Gene info

• Identity
  HGNC:1864
• Gene
  CES2
• Long gene name
  carboxylesterase 2
• Synonyms gene name
  • carboxylesterase 2 (intestine, liver)
• Synonyms
  • CE-2
  • iCE
  • CES2A1
• GenBank acession
  • BC032095
• Locus
  16q22.1
• Discovery year
  1993-09-30
• Entrez gene record
  8824
• Pubmed identfication
  • 9169443
  • 9144407
  • 20931200
• RefSeq identity
  • NM_003869
• Classification
  • Carboxylesterases
• VEGA ID
  OTTHUMG00000137517

Gene info

• Identity
  HGNC:28861
• Gene
  CARD18
• Long gene name
  caspase recruitment domain family member 18
• Synonyms gene name
  • caspase recruitment domain family, member 18
• Synonyms
  • UNQ5804
  • ICEBERG
  • pseudo-ICE
• GenBank acession
  • AY358231
• Locus
  11q22.3
• Discovery year
  2008-09-02
• Entrez gene record
  59082
• Pubmed identfication
  • 11051551
• RefSeq identity
  • NM_021571
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166165

Gene info

• Identity
  HGNC:33701
• Gene
  CARD16
• Long gene name
  caspase recruitment domain family member 16
• Synonyms gene name
  • caspase recruitment domain family, member 16
• Synonyms
  • COP1
  • COP
  • PSEUDO-ICE
  • LLID-114769
• Locus
  11q22.3
• Discovery year
  2008-09-15
• Entrez gene record
  114769
• Pubmed identfication
  • 11432859
  • 11536016
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166157

Gene info

• Identity
  HGNC:1505
• Gene
  CASP4
• Long gene name
  caspase 4
• Synonyms gene name
  • caspase 4, apoptosis-related cysteine protease
  • caspase 4, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)II
  • ICH-2
  • TX
• GenBank acession
  • U25804
• Locus
  11q22.3
• Discovery year
  1996-07-22
• Entrez gene record
  837
• Pubmed identfication
  • 7797510
  • 9250871
• RefSeq identity
  • NM_001225
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166078

Gene info

• Identity
  HGNC:1511
• Gene
  CASP9
• Long gene name
  caspase 9
• Synonyms gene name
  • caspase 9, apoptosis-related cysteine protease
  • caspase 9, apoptosis-related cysteine peptidase
• Synonyms
  • MCH6
  • ICE-LAP6
  • APAF-3
  • PPP1R56
• Synonyms name
  • protein phosphatase 1, regulatory subunit 56
• GenBank acession
  • U60521
• Locus
  1p36.21
• Discovery year
  1996-11-11
• Entrez gene record
  842
• Pubmed identfication
  • 8663294
  • 9390557
• RefSeq identity
  • NM_032996
• Classification
  • Caspases
  • Apoptosome
  • Caspase recruitment domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000002256

Gene info

• Identity
  HGNC:1508
• Gene
  CASP7
• Long gene name
  caspase 7
• Synonyms gene name
  • caspase 7, apoptosis-related cysteine protease
  • caspase 7, apoptosis-related cysteine peptidase
• Synonyms
  • MCH3
  • CMH-1
  • ICE-LAP3
• GenBank acession
  • U37448
• Locus
  10q25.3
• Discovery year
  1996-07-22
• Entrez gene record
  840
• Pubmed identfication
  • 8521391
  • 8576161
• RefSeq identity
  • NM_033338
• Classification
  • Caspases
• VEGA ID
  OTTHUMG00000019076

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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