Antitrypsin Activated Protein C (APC-AAT complexes, alpha1 Proteinase Inhibitor, alpha1 PI, native and denatured)

• Catalog number
  MBS601232
• Price
  Please ask
• Size
  0.1 mL

• Products_type
  Antibody
• Products_short_name
  [Antitrypsin Activated Protein C]
• Products_name_syn
  [Anti -Antitrypsin Activated Protein C (APC-AAT complexes, alpha1 Proteinase Inhibitor, alpha1 PI, native and denatured)]
• Other_names
  [alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3]
• Other_gene_names
  [SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; AACT; ACT]
• Clonality
  Monoclonal
• Clone
  [7]
• Reactivity
  Human
• Specificity
  Has specificity for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with a1-antitrypsin. No reaction is seen to non-complexed a1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.
• Purity
  Affinity Purified Purified by Protein A/G affinity chromatography from culture supernatant.
• Form
  Supplied as a liquid in PBS, pH 7.2, 15mM sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  ELISA (EL/EIA)
• Description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Antitrypsin   Activated   Protein   APC-AAT   complexes   alpha1   Proteinase   Inhibitor   alpha1   native   denatured  
• Gene symbol
  APC, TRI-AAT1-1, TRI-AAT4-1, TRI-AAT7-1, TRI-AAT3-1, TRI-AAT11-1, TRI-AAT7-2, TRI-AAT12-1, TRI-AAT2-1, TRI-AAT6-1
• Short name
  Antitrypsin Activated Protein C (APC-AAT complexes, alpha1 Proteinase Inhibitor, alpha1 PI, native denatured)
• Host
  Mouse
• Isotype
  IgG1,k
• Label
  APC
• Alternative name
  Antitrypsin Activated Protein C (adenomatous polyposis coli-AAT complexes, alpha1 Proteinase suppressor, alpha1 PI, native and denaturation)
• Alternative to gene target
  adenomatous polyposis coli, BTPS2 and DP2 and DP2.5 and DP3 and GS and PPP1R46, APC and IDBG-37007 and ENSG00000134982 and 324, microtubule plus-end binding, nuclei, Apc and IDBG-134573 and ENSMUSG00000005871 and 11789, BT.25770 and IDBG-644937 and ENSBTAG00000018852 and 533233

Gene info

• Identity
  HGNC:583
• Gene
  APC
• Long gene name
  APC regulator of WNT signaling pathway
• Synonyms gene name
  • adenomatosis polyposis coli
  • adenomatous polyposis coli
  • APC, WNT signaling pathway regulator
• Synonyms
  • DP2
  • DP3
  • DP2.5
  • PPP1R46
• Synonyms name
  • protein phosphatase 1, regulatory subunit 46
• GenBank acession
  • M74088
• Locus
  5q22.2
• Discovery year
  1986-01-01
• Entrez gene record
  324
• Pubmed identfication
  • 1651563
• RefSeq identity
  • NM_000038
• Classification
  • Protein phosphatase 1 regulatory subunits
  • Armadillo repeat containing
• VEGA ID
  OTTHUMG00000128806
• Locus Specific Databases
  • Adenomatous polyposis coli mutation database
  • UMD Locus Specific Databases
  • Global Variome shared LOVD
  • APC database at LOVD-China
  • LOVD - Leiden Open Variation Database
  • LRG_130

Gene info

• Identity
  HGNC:34812
• Gene
  TRI-AAT1-1
• Long gene name
  tRNA-Ile (anticodon AAT) 1-1
• Synonyms gene
  • TRNAI12
• Synonyms gene name
  • transfer RNA isoleucine 12 (anticodon AAU)
  • transfer RNA-Ile (AAT) 1-1
• Synonyms
  • tRNA-Ile-AAT-1-1
• GenBank acession
  • HG983843
• Locus
  6p11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189249
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34961
• Gene
  TRI-AAT4-1
• Long gene name
  tRNA-Ile (anticodon AAT) 4-1
• Synonyms gene
  • TRNAI24
• Synonyms gene name
  • transfer RNA isoleucine 24 (anticodon AAU)
  • transfer RNA-Ile (AAT) 4-1
• Synonyms
  • tRNA-Ile-AAT-4-1
• GenBank acession
  • HG983846
• Locus
  17p13.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189393
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34710
• Gene
  TRI-AAT7-1
• Long gene name
  tRNA-Ile (anticodon AAT) 7-1
• Synonyms gene
  • TRNAI8
• Synonyms gene name
  • transfer RNA isoleucine 8 (anticodon AAU)
  • transfer RNA-Ile (AAT) 7-1
• Synonyms
  • tRNA-Ile-AAT-7-1
• GenBank acession
  • HG983853
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189401
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34776
• Gene
  TRI-AAT3-1
• Long gene name
  tRNA-Ile (anticodon AAT) 3-1
• Synonyms gene
  • TRNAI11
• Synonyms gene name
  • transfer RNA isoleucine 11 (anticodon AAU)
  • transfer RNA-Ile (AAT) 3-1
• Synonyms
  • tRNA-Ile-AAT-3-1
• GenBank acession
  • HG983845
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189213
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35047
• Gene
  TRI-AAT11-1
• Long gene name
  tRNA-Ile (anticodon AAT) 11-1
• Synonyms gene
  • TRNAI29P
• Synonyms gene name
  • transfer RNA isoleucine 29 (anticodon AAU) pseudogene
  • transfer RNA-Ile (AAT) 11-1
• Synonyms
  • tRNA-Ile-AAT-11-1
• GenBank acession
  • HG983858
• Locus
  12q24.33
• Discovery year
  2008-08-29
• Entrez gene record
  100189474
• RefSeq identity
  • NG_008532
• Classification
  • Cytoplasmic transfer RNA pseudogenes

Gene info

• Identity
  HGNC:34970
• Gene
  TRI-AAT7-2
• Long gene name
  tRNA-Ile (anticodon AAT) 7-2
• Synonyms gene
  • TRNAI25
• Synonyms gene name
  • transfer RNA isoleucine 25 (anticodon AAU)
  • transfer RNA-Ile (AAT) 7-2
• Synonyms
  • tRNA-Ile-AAT-7-2
• GenBank acession
  • HG983854
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  107986683
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35054
• Gene
  TRI-AAT12-1
• Long gene name
  tRNA-Ile (anticodon AAT) 12-1
• Synonyms gene
  • TRNAI30P
• Synonyms gene name
  • transfer RNA isoleucine 30 (anticodon AAU) pseudogene
  • transfer RNA-Ile (AAT) 12-1
• Synonyms
  • tRNA-Ile-AAT-12-1
• GenBank acession
  • HG983859
• Locus
  20q13.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189481
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34630
• Gene
  TRI-AAT2-1
• Long gene name
  tRNA-Ile (anticodon AAT) 2-1
• Synonyms gene
  • TRNAI4
• Synonyms gene name
  • transfer RNA isoleucine 4 (anticodon AAU)
  • transfer RNA-Ile (AAT) 2-1
• Synonyms
  • tRNA-Ile-AAT-2-1
• GenBank acession
  • HG983844
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189071
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34940
• Gene
  TRI-AAT6-1
• Long gene name
  tRNA-Ile (anticodon AAT) 6-1
• Synonyms gene
  • TRNAI22
• Synonyms gene name
  • transfer RNA isoleucine 22 (anticodon AAU)
  • transfer RNA-Ile (AAT) 6-1
• Synonyms
  • tRNA-Ile-AAT-6-1
• GenBank acession
  • HG983852
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189372
• Classification
  • Cytoplasmic transfer RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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