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Alternative name1
Anti-RABBIT ANTI HUMAN CD82 (C-TERMINAL)
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Alternative name2
RABBIT ANTI HUMAN CD82 (C-TERMINAL)
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Alternative name3
Lapin ANTI Homo sapiens CD82 (C-TERMINAL)
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Alternative name4
CD82
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Alternative name5
N/A
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Other names
CD82 antigen isoform 2; CD82 antigen; CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); CD82 molecule; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27
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Gene name
CD82
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Gene name synonims
N/A
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Other gene names
CD82; CD82; R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27; KAI1; SAR2; ST6; TSPAN27; Tspan-27
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Human
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Specificity and cross reactivity
CD82 This item recognises the human CD82 antigen, also known as KAI1, SAR2 and TSPAN27, a multi-pass membrane protein of approximately 30kDa belonging to the tetraspanin (TM4SF) family. _x000D__x000D_CD82 has been identified as a cancer metastasis suppressor protein, while ubiquitously expressed at moderate to high levels in many normal tissues, its expression is down regulated during tumour progression. Loss of CD82 and p53 is correlated with poor prognosis for patients with prostate and other forms of cancer. _x000D__x000D_Research has demonstrated that CD82 interacts with CD234 (DARC). It has been hypothesized that tumour cells dislodged from the primary tumour and expressing CD82 interact with CD234 expressed on vascular cells, transmitting a senescent signal to the tumour cells. Tumour cells that have lost CD82 expression can proliferate and potentially give rise to metastases. _x000D__x000D_It has been demonstrated that at least two isoforms of CD82 exist.
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
IgG concentration 1.0mg/ml
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. Storage in frost-free freezers is not recommended. productone should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Immunohistology - Paraffin (IHC), Western Blot (WB)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
MBS Polyclonals supplies antibodies that are for research of human proteins.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
