MOUSE Anti-HUMAN HIF1 ALPHA Antibody

• Catalog number
  GEN219820
• Price
  Please ask
• Size
  200ug

• Also known as
  HIF1 ALPHA
• Other names
  hypoxia-inducible factor 1-alpha isoform 3; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor 1-alpha; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; hypoxia-inducible factor1alpha; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  HIF1 ALPHA
• Gene name synonims
  N/A
• Other gene names
  HIF1A; HIF1A; HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; BHLHE78; MOP1; PASD8; HIF-1-alpha; HIF1-alpha; bHLHe78
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2a
• Clone
  Halpha111a
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  HIF1 ALPHA This item specifically recognizes human HIF1 alpha (HIF1A), otherwise known as Hypoxia-inducible factor 1-alpha, a widely expressed bHLH-PAS transcription factor, which acts as a critical regulatory protein in the host response to oxygen depravation (hypoxia). _x000D__x000D_HIF1A and HIF1B (HIF1 beta/ARNT) form the highly-conserved heterodimeric HIF-1 transcriptional complex. During hypoxic conditions, HIF1A accumulates in the nucleus and activates the transcription of many genes encoding proteins involved in the production of oxygen delivery and metabolic adaptation, such as vascular endothelial growth factor (VEGF) and glucose transporters. Under normal oxygen conditions, HIF1A is targeted by HIF prolyl-hydroxylase, followed by rapid protease degradation, which is inhibited during hypoxia. _x000D__x000D_Overexpression of HIF1A occurs in many common human cancers, including pancreatic, bladder and renal carcinomas.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  Purified (Purified IgG - liquid)
• Concentration
  IgG concentration 1.0mg/ml
• Storage and shipping
  Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term.Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from the date of dispatch.
• Tested applications
  Immunohistology - Paraffin (IHC)
• Description
  The MOUSE Anti- HIF1 ALPHA Antibody is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Test
  MBS Monoclonals supplies antibodies that are for research of human proteins. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  HIF1   ALPHA  
• Gene symbol
  SRPRA, CBX5, AGPAT1, DRAP1, SCART1, TUBA3D, HIF1A, TLK2, CAMK1, CTNNAL1
• Short name
  MOUSE Anti- HIF1 ALPHA Antibody
• Technique
  anti-Human, Antibody, anti-, Mouse, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, antibodies against human proteins, mouses
• Host
  mouse
• Species
  Human, Humans, Mouses
• Alternative name
  Anti-MOUSE ANTI HUMAN HIF1 ALPHA
• Alternative technique
  antibodies, murine

Gene info

• Identity
  HGNC:11307
• Gene
  SRPRA
• Long gene name
  SRP receptor subunit alpha
• Synonyms gene
  • SRPR
• Synonyms gene name
  • signal recognition particle receptor (docking protein)
• Synonyms
  • SRP-alpha
  • Sralpha
  • SR-alpha
• GenBank acession
  • BC001162
• Locus
  11q24.2
• Discovery year
  2001-06-22
• Entrez gene record
  6734
• Pubmed identfication
  • 3340536
  • 1312991
• RefSeq identity
  • NM_003139
• VEGA ID
  OTTHUMG00000165826

Gene info

• Identity
  HGNC:1555
• Gene
  CBX5
• Long gene name
  chromobox 5
• Synonyms gene name
  • chromobox homolog 5 (Drosophila HP1 alpha)
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila)
  • chromobox homolog 5
• Synonyms
  • HP1Hs-alpha
  • HP1
  • HP1-ALPHA
• Synonyms name
  • HP1 alpha homolog (Drosophila)
• GenBank acession
  • U26311
• Locus
  12q13.13
• Discovery year
  1999-10-12
• Entrez gene record
  23468
• Pubmed identfication
  • 8663349
• RefSeq identity
  • NM_012117
• Classification
  • Chromobox family
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000169700

Gene info

• Identity
  HGNC:324
• Gene
  AGPAT1
• Long gene name
  1-acylglycerol-3-phosphate O-acyltransferase 1
• Synonyms gene name
  • 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
• Synonyms
  • LPAAT-alpha
• Synonyms name
  • lysophosphatidic acid acyltransferase, alpha
• GenBank acession
  • U56417
• Locus
  6p21.32
• Discovery year
  1999-12-07
• Entrez gene record
  10554
• Pubmed identfication
  • 9461603
  • 9291118
• RefSeq identity
  • NM_006411
• Classification
  • MicroRNA protein coding host genes
  • 1-acylglycerol-3-phosphate O-acyltransferases
• VEGA ID
  OTTHUMG00000031210

Gene info

• Identity
  HGNC:3019
• Gene
  DRAP1
• Long gene name
  DR1 associated protein 1
• Synonyms
  • NC2-alpha
• Synonyms name
  • negative cofactor 2 alpha
  • DR1-associated corepressor
• GenBank acession
  • U41843
• Locus
  11q13.1
• Discovery year
  1998-09-22
• Entrez gene record
  10589
• Pubmed identfication
  • 8608938
• RefSeq identity
  • NM_006442
• VEGA ID
  OTTHUMG00000166723

Gene info

• Identity
  HGNC:32411
• Gene
  SCART1
• Long gene name
  scavenger receptor family member expressed on T cells 1
• Synonyms gene name
  • scavenger receptor family member expressed on T-cells 1
• Synonyms
  • CD163c-alpha
• Locus
  10q26.3
• Discovery year
  2017-02-28
• Entrez gene record
  619207
• Pubmed identfication
  • 19297026
  • 22795646
• RefSeq identity
  • NM_001396050
• Classification
  • Scavenger receptor cysteine rich domain containing

Gene info

• Identity
  HGNC:24071
• Gene
  TUBA3D
• Long gene name
  tubulin alpha 3d
• Synonyms
  • H2-ALPHA
• Synonyms name
  • alpha-tubulin isotype H2-alpha
• GenBank acession
  • K03460
• Locus
  2q21.1
• Discovery year
  2007-02-12
• Entrez gene record
  113457
• Pubmed identfication
  • 3785200
• RefSeq identity
  • NM_080386
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000153600

Gene info

• Identity
  HGNC:4910
• Gene
  HIF1A
• Long gene name
  hypoxia inducible factor 1 subunit alpha
• Synonyms gene name
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
• Synonyms
  • MOP1
  • HIF-1alpha
  • PASD8
  • HIF1
  • bHLHe78
• Synonyms name
  • PAS domain-containing protein 8”, “Class E basic helix-loop-helix protein 78”, “Member of PAS protein 1
• GenBank acession
  • U22431
• Locus
  14q23.2
• Discovery year
  1995-03-27
• Entrez gene record
  3091
• Pubmed identfication
  • 8786149
  • 9079689
• RefSeq identity
  • NM_001530
• Classification
  • Basic helix-loop-helix proteins
• VEGA ID
  OTTHUMG00000140344

Gene info

• Identity
  HGNC:11842
• Gene
  TLK2
• Long gene name
  tousled like kinase 2
• Synonyms gene name
  • tousled-like kinase 2
• Synonyms
  • PKU-ALPHA
  • MGC44450
• GenBank acession
  • AB004884
• Locus
  17q23.2
• Discovery year
  2000-01-07
• Entrez gene record
  11011
• Pubmed identfication
  • 9427565
  • 10523312
• RefSeq identity
  • NM_006852
• VEGA ID
  OTTHUMG00000179176

Gene info

• Identity
  HGNC:1459
• Gene
  CAMK1
• Long gene name
  calcium/calmodulin dependent protein kinase I
• Synonyms
  • CaMKI
  • CaMKI-alpha
• GenBank acession
  • L41816
• Locus
  3p25.3
• Discovery year
  1998-10-16
• Entrez gene record
  8536
• Pubmed identfication
  • 7641687
• RefSeq identity
  • NM_003656
• Classification
  • Calmodulin dependent protein kinases
• VEGA ID
  OTTHUMG00000128419

Gene info

• Identity
  HGNC:2512
• Gene
  CTNNAL1
• Long gene name
  catenin alpha like 1
• Synonyms gene name
  • catenin (cadherin-associated protein), alpha-like 1
  • catenin alpha-like 1
• Synonyms
  • CLLP
  • alpha-CATU
• Synonyms name
  • alpha-catulin
  • alpha2-catulin
• GenBank acession
  • AF030233
• Locus
  9q31.3
• Discovery year
  1998-12-09
• Entrez gene record
  8727
• Pubmed identfication
  • 9806841
• RefSeq identity
  • NM_003798
• VEGA ID
  OTTHUMG00000020466

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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