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anti-DR3 (Death Receptor 3/Apo3) Polyclonal Antibody

  • Catalog number
    3057-100
  • Product name
    anti-DR3 (Death Receptor 3/Apo3) Polyclonal Antibody
  • Size
    DR3 (Death Receptor 3/Apo3) Polyclonal Antibody
  • Price
    316EUR
  • Supplier
    biovision antibodies-kits-proteins
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  • Antibody host:
    Rabbit
  • This antibody reacts with:
    Human, Mouse, Rat
  • Purification method:
    Affinity purified rabbit IgG
  • Immunogene sequence:
    Synthetic peptide corresponding to residues surrounding amino acids 400 of human DR3.
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot
  • Target of this antibody:
    DR3 (Death Receptor 3/Apo3)
  • Formulation of this antibody:
    100 µg (0.5 mg/ml) antigen affinity-purified rabbit anti-DR3/Apo3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
  • Alternative names of antibody target:
    Apo 3, LARD, TNFRSF12, TRAMP, TNFRSF25, WSL1
  • Recommended usage:
    Western blot: 1-4 µg
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    rabbit IgG
  • Clone:
    N/A
  • Background information:
    Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily through interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis through TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.
  • Concentration of antibody:
    0.5 mg/ml
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
  • Gene target
  • Short name
    anti-DR3 (Death Receptor 3/Apo3) Polyclonal Antibody
  • Technique
    Polyclonal, antibody to, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Alternative name
    antibody to-DR3 (Death Receptor 3/Apo3) polyclonal (Antibody to)
  • Alternative technique
    polyclonals
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1. Gene info
  • Identity
  • Gene
  • Long gene name
    TNF receptor superfamily member 25
  • Synonyms gene
  • Synonyms gene name
    • tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
    • tumor necrosis factor receptor superfamily, member 25
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1998-12-04
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Tumor necrosis factor receptor superfamily
  • Havana BLAST/BLAT
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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