FASL Antibody

• Catalog number
  PB9068
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  FASL
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human Predicted to work with: mouse, rat
• Analyses
  WB,IHC-P
• Immunogen
  E.coli-derived mouse Fas Ligand recombinant protein (Position: Q128-L279). Mouse Fas Ligand shares 82% and 93% amino acid (aa) sequences identity with human and rat, respectively.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the FASL Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The FASL Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. It is mapped to 1q24.3. FASL may contribute to the immune privilege of tumors. Pharmacologic products that render infiltrating T cells insensitive to FASL-induced killing may break the immunologic unresponsiveness to melanoma and provide a complementary approach in the therapy of malignant melanoma. FASL-mediated apoptosis is important for skin homeostasis, the dysregulation of FAS-FASL interactions may be central to the development of skin cancer. Polymorphisms affecting either the expression or biologic activities of FAS or FASL may contribute to the genetic risk of developing T-cell lymphoblastic lymphomas.
• Related articles
  1. Hahne, M., Rimoldi, D., Schroter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., Cerottini, J. C., Tschopp, J. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape.Science 274: 1363-1366, 1996. 2. Hill, L. L., Ouhtit, A., Loughlin, S. M., Kripke, M. L., Ananthaswamy, H. N., Owen-Schaub, L. B. Fas ligand: a sensor for DNA damage critical in skin cancer etiology.Science 285: 898-900, 1999. 3. Villa-Morales, M., Santos, J., Perez-Gomez, E., Quintanilla, M., Fernandez-Piqueras, J. A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas. Cancer Res. 67: 5107-5116, 2007.
• Gene Name
  FASLG
• Protein Name
  Tumor necrosis factor ligand superfamily member 6
• Gene Full Name
  Fas ligand (TNF superfamily, member 6)
• Synonyms
  ALPS1B antibody|APO1L antibody|Apoptosis (APO 1) antigen ligand 1 antibody|Apoptosis antigen ligand 1 antibody|Apoptosis antigen ligand antibody|APT1LG1 antibody|APTL antibody|CD178 antibody|CD178 antigen antibody|CD95 ligand antibody|CD95-L antibody|CD95L antibody|CD95L protein antibody|Fas antigen ligand antibody|Fas L antibody|Fas ligand (TNF superfamily member 6) antibody|Fas ligand antibody|FASL antibody|Fasl Fas ligand (TNF superfamily member 6) antibody|FASLG antibody|Generalized lymphoproliferative disease antibody|Gld antibody|soluble form antibody|TNF superfamily member 6 antibody|TNFL6_HUMAN antibody|TNFSF6 antibody|Tumor necrosis factor (ligand) superfamily member 6 antibody|Tumor necrosis factor ligand superfamily member 6 antibody
• Uniprot ID
  P41047
• Entrez GeneID
  14103
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FASL  
• Gene symbol
  FASLG
• Short name
  FASL Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  FASL (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11936
• Gene
  FASLG
• Long gene name
  Fas ligand
• Synonyms gene
  • APT1LG1
  • TNFSF6
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 6
  • Fas ligand (TNF superfamily, member 6)
• Synonyms
  • FasL
  • CD178
• GenBank acession
  • U11821
• Locus
  1q24.3
• Discovery year
  1994-12-09
• Entrez gene record
  356
• Pubmed identfication
  • 7826947
  • 9022072
• Classification
  • Tumor necrosis factor superfamily
  • Death inducing signaling complex
  • CD molecules
• VEGA ID
  OTTHUMG00000034841
• Locus Specific Databases
  • FASLGbase: Mutation registry for Autoimmune lymphoproliferative syndrome, type 1B (ALPS1B) (previously known as TNFSF6base)
  • LRG_58

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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