- Catalog numberPA1576
- Product nameFASL Antibody
- Size0,1 mg
- PriceAsk For Price
- Target antigenFASL
- ClonalityPolyclonal antibody
- ClonePolyclonal antibody
- Raised inrabbit
- Type of the antibodyIgG polyclonal antibody
- Product formfreeze-dried
- Reacts with specieshuman
- AnalysesWB,IHC-P
- ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human Fas Ligand(263-281aa ELSLVNFEESQTFFGLYKL).
- Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
- PurificationImmunogen affinity purified.
- SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
- Storage condtionsKeep the FASL Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
- TipsThe FASL Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
- BackgroundFas ligand(FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor(TNF) family. Its binding with its receptor induces apoptosis. The human FASL gene consists of approximately 8 kb and is split into 4 exons. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Fas ligand or FasL is a homotrimeric type II transmembrane protein. It signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7.
- Related articles1. Asanuma, K., Tsuji, N., Endoh, T., Yagihashi, A., Watanabe, N.Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells.J. Immun. 172: 3922-3929, 2004. 2. Hahne, M., Rimoldi, D., Schroter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., Cerottini, J. C., Tschopp, J.Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape.Science 274: 1363-1366, 1996. 3. Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., Nishina, H., Takeda, S., Takayanagi, H., Metzger, D., Kanno, J., Takaoka, K., Martin, T. J., Chambon, P., Kato, S.Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.Cell 130: 811-823, 2007.
- Gene NameFASLG
- Protein NameTumor necrosis factor ligand superfamily member 6
- Gene Full NameFas ligand(TNF superfamily, member 6)
- SynonymsALPS1B antibody|APO1L antibody|Apoptosis(APO 1) antigen ligand 1 antibody|Apoptosis antigen ligand 1 antibody|Apoptosis antigen ligand antibody|APT1LG1 antibody|APTL antibody|CD178 antibody|CD178 antigen antibody|CD95 ligand antibody|CD95-L antibody|CD95L antibody|CD95L protein antibody|FAS antigen ligand antibody|Fas L antibody|Fas ligand(TNF superfamily member 6) antibody|Fas ligand antibody|FASL antibody|Fasl Fas ligand(TNF superfamily member 6) antibody|FASLG antibody|Generalized lymphoproliferative disease antibody|Gld antibody|soluble form antibody|TNF superfamily member 6 antibody|TNFL6_HUMAN antibody|TNFSF6 antibody|Tumor necrosis factor(ligand) superfamily member 6 antibody|Tumor necrosis factor ligand superfamily member 6 antibody
- Uniprot IDP48023
- Gene targetFASL
- Identity:HGNC:11936
- Gene:FASLG
- Long gene name:Fas ligand
- Synonyms gene name:tumor necrosis factor (ligand) superfamily, member 6, Fas ligand (TNF superfamily, member 6)
- Synonyms:FasL, CD178
- Discovery year:1994-12-09
- Entrez gene record:356
- Pubmed identification:7826947, 9022072
- Classification:Tumor necrosis factor superfamily, Death inducing signaling complex, CD molecules
- VEGA ID:OTTHUMG00000034841
- Gene symbolFASLG
- Short nameFASL Antibody
- technique filter
- Antibody
- TechniqueAntibody, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies