DISC1 Antibody
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Catalog numberR31132
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenDISC1
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB, IHC-P
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Recommended dilutionsWestern blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,Mouse
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NotesThe stated application concentrations are suggested starting amounts. Titration of the DISC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis DISC1 antibodyis to be used only for research purposes and not for diagnostics..
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UniprotQ9NRI5
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PurityAntigen affinity
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DescriptionDisrupted in Schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that the protein interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.
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ImmunogenAn amino acid sequence from the middle region of human Disrupted in Schizophrenia 1 (EKQQLQKEIEALQARMF) was used as the immunogen for this DISC1 antibody.
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StorageAfter reconstitution, the DISC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolDISC1, TSNAX-DISC1, DISC1-IT1, DISC2
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Short nameAnti-DISC1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to DISC1
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameDISC1 scaffold protein
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Synonyms gene name
- disrupted in schizophrenia 1
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTSNAX-DISC1 readthrough (NMD candidate)
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Locus
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Discovery year2013-09-24
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameDISC1 intronic transcript 1
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Synonyms gene name
- DISC1 intronic transcript 1 (non-protein coding)
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Locus
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Discovery year2011-05-20
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Classification
- Intronic transcripts
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedisrupted in schizophrenia 2
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Synonyms gene name
- disrupted in schizophrenia 2 (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long non-coding RNAs with non-systematic symbols
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data