DISC1 Antibody

• Catalog number
  R31131
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  DISC1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the DISC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This DISC1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9NRI5
• Purity
  Antigen affinity
• Description
  Disrupted in Schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that the protein interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.
• Immunogen
  An amino acid sequence from the N-terminus of human Disrupted in Schizophrenia 1 (EESHHSESRARQCGLDSR) was used as the immunogen for this DISC1 antibody.
• Storage
  After reconstitution, the DISC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DISC1  
• Gene symbol
  DISC1, TSNAX-DISC1, DISC1-IT1, DISC2
• Short name
  Anti-DISC1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to DISC1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2888
• Gene
  DISC1
• Long gene name
  DISC1 scaffold protein
• Synonyms gene name
  • disrupted in schizophrenia 1
• GenBank acession
  • AF222980
• Locus
  1q42.2
• Discovery year
  2000-01-20
• Entrez gene record
  27185
• Pubmed identfication
  • 10814723
• RefSeq identity
  • NM_018662
• VEGA ID
  OTTHUMG00000037835

Gene info

• Identity
  HGNC:49177
• Gene
  TSNAX-DISC1
• Long gene name
  TSNAX-DISC1 readthrough (NMD candidate)
• Locus
  1q42.2
• Discovery year
  2013-09-24
• Entrez gene record
  100303453
• VEGA ID
  OTTHUMG00000183905

Gene info

• Identity
  HGNC:41325
• Gene
  DISC1-IT1
• Long gene name
  DISC1 intronic transcript 1
• Synonyms gene name
  • DISC1 intronic transcript 1 (non-protein coding)
• Locus
  1q42.2
• Discovery year
  2011-05-20
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000037834

Gene info

• Identity
  HGNC:2889
• Gene
  DISC2
• Long gene name
  disrupted in schizophrenia 2
• Synonyms gene name
  • disrupted in schizophrenia 2 (non-protein coding)
• Synonyms
  • DISC1-AS1
  • DISC1OS
  • NCRNA00015
• Synonyms name
  • DISC1 antisense RNA 1
  • non-protein coding RNA 15
• GenBank acession
  • AF222981
• Locus
  1q42.1
• Discovery year
  2000-01-20
• Entrez gene record
  27184
• Pubmed identfication
  • 10814723
  • 15478311
• RefSeq identity
  • NR_002227
• Classification
  • Long non-coding RNAs with non-systematic symbols

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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