CtBP1 Antibody

• Catalog number
  R30646
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  CtBP1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the CtBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This CtBP1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q13363
• Purity
  Antigen affinity
• Description
  C-terminal-binding protein 1 is encoded by the CTBP1 gene. It binds to the C-terminus of adenovirus E1A proteins. It is a transcriptional repressor(corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and -2 associate with the PLDLSL domain of delta EF1, a cellular zinc finger-homeodomain protein, and thereby enhances delta EF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
• Immunogen
  Amino acids 425-440 (QTVKPEADRDHASDQL-human) were used as the immunogen for this CtBP1 antibody.
• Storage
  After reconstitution, the CtBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CtBP1  
• Gene symbol
  CTBP1-DT, CTBP1-AS, CTBP1
• Short name
  Anti-CtBP1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to CtBP1
• Alternative technique
  antibodies
• Alternative to gene target
  C-terminal binding protein 1, BARS, CTBP1 and IDBG-6522 and ENSG00000159692 and 1487, oxidoreductase activity, nuclei, Ctbp1 and IDBG-152845 and ENSMUSG00000037373 and 13016, CTBP1 and IDBG-643874 and ENSBTAG00000008480 and 513131

Gene info

• Identity
  HGNC:28307
• Gene
  CTBP1-DT
• Long gene name
  CTBP1 divergent transcript
• Synonyms gene
  • C4orf42
  • CTBP1-AS1
  • CTBP1-AS2
• Synonyms gene name
  • chromosome 4 open reading frame 42
  • CTBP1 antisense RNA 1 (head to head)
  • CTBP1 antisense RNA 2 (head to head)
• Synonyms
  • MGC21675
• GenBank acession
  • AK056133
• Locus
  4p16.3
• Discovery year
  2007-12-19
• Entrez gene record
  92070
• Pubmed identfication
  • 31220774
• RefSeq identity
  • NR_033339
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000160166

Gene info

• Identity
  HGNC:48337
• Gene
  CTBP1-AS
• Long gene name
  CTBP1 antisense RNA
• Synonyms
  • PCAT10
• Synonyms name
  • prostate cancer associated transcript 10
• GenBank acession
  • AX747592
  • AK092548
• Locus
  4p16.3
• Discovery year
  2013-06-14
• Entrez gene record
  285463
• Pubmed identfication
  • 23644382
  • 25552498
• RefSeq identity
  • NR_104331
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000189534

Gene info

• Identity
  HGNC:2494
• Gene
  CTBP1
• Long gene name
  C-terminal binding protein 1
• Synonyms
  • BARS
• Synonyms name
  • brefeldin A-ribosylated substrate
• GenBank acession
  • U37408
• Locus
  4p16.3
• Discovery year
  1997-08-22
• Entrez gene record
  1487
• Pubmed identfication
  • 9479502
• RefSeq identity
  • NM_001328
• VEGA ID
  OTTHUMG00000089259

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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