IGF I protein

Category

Proteins
Antibody Subtype

Recombinant Proteins
Area of research

Cytokines & Growth Factors
Reactivity

Human
Type of protein

Recombinant
Expression System

Escherichia coli
Grade Purity

Grater than 95% pure
Method of Purification

IGF I protein was purified using a a proprietary chromatographic technique.
Form Buffer

Provided in lyophilized form with no additives
Storage

Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Shipping conditions

Blue Ice
Bioactivity

The ED50 was determined by two methods: 1) By stimulation of protein synthesis in rat L6 myoblasts,
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Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.