NTAL / LAB monoclonal antibody

• Catalog number
  11-373-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human NTAL / LAB, Clone: NAP-03
• Antigen
  NTAL / LAB
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  Mouse
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  NAP-03
• Applications
  IP, WB, IHC(P)
• Immunogen
  Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
• Format conjugation
  purified; unconjugated
• Specificity
  The antibody NAP-03 recognizes the defined epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
• Research area
  Adaptor Proteins (Human), Adaptor Proteins
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human NTAL / LAB, Clone: NAP-03 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  NTAL (Non-T cell Activation Linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Brdicka T, Imrich M, Angelisova P, Brdickova N, Horvath O, Spicka J, Hilgert I, Luskova P, Draber P, Novak P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsi V: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002 Dec 16;196(12):1617-26. _x000D_
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  NTAL   LAB   monoclonal  
• Gene symbol
  LAT2
• Short name
  Anti-NTAL / LAB Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2a
• Alternative name
  Mouse Monoclonal to NTAL / LAB
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12749
• Gene
  LAT2
• Long gene name
  linker for activation of T cells family member 2
• Synonyms gene
  • WBSCR15
  • WBSCR5
• Synonyms gene name
  • Williams-Beuren syndrome chromosome region 5
  • linker for activation of T cells family, member 2
  • linker for activation of T-cells family member 2
• Synonyms
  • WSCR5
  • HSPC046
  • LAB
  • NTAL
• Synonyms name
  • linker for activation of B cells
  • non-T cell activation linker
  • linker for activation of T cells, transmembrane adaptor 2
• GenBank acession
  • AF257135
• Locus
  7q11.23
• Discovery year
  1997-09-12
• Entrez gene record
  7462
• Pubmed identfication
  • 8812460
  • 12514734
• VEGA ID
  OTTHUMG00000130151

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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