LAT monoclonal antibody
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Catalog number11-360-C100
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PricePlease ask
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Size100ug
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Long nameMouse Monoclonal Antibody against Human LAT, Clone: LAT-01
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AntigenLAT
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Species reactivityHuman (Homo sapiens)
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Negative species reactivityMouse, Other not tested
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ClonalityMonoclonal Antibody (Mab)
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CloneLAT-01
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ApplicationsWB, IP, FC
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ImmunogenBacterially produced recombinant polypeptide _x000D_ corresponding to the entire cytoplasmic domain of human LAT.
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Format conjugationpurified; unconjugated
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SpecificityThe antibody LAT-01 reacts with Linker for activation of T cells (LAT), a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
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Research areaAdaptor Proteins (Human), Adaptor Proteins
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Concentration1 mg/ml
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Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Shipping and storageMouse Monoclonal Antibody against Human LAT, Clone: LAT-01 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
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BackgroundLAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
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Purity> 95% (by SDS-PAGE)
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Purification methodPurified by protein-A affinity chromatography
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References*Hrdinka M, Dráber P, Stepánek O, Ormsby T, Otáhal P, Angelisová P, Brdicka T, Paces J, Horejsí V, Drbal K: PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem. 2011 Jun 3;286(22):19617-29., *Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V.: Transmembrane adaptor molecules: a new category of lymphoid-cell markers._x000D_ Blood. 2006 Jan 1;107(1):213-21. _x000D_
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PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translationanticorps
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Gene target
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Gene symbolLAT, SLC7A6, SLC7A7, SPNS1
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Short nameAnti-LAT Mab
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TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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HostMouse (Mus musculus)
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IsotypeIgG1
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Alternative nameMouse Monoclonal to LAT
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Alternative techniqueantibodies
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Alternative to gene targetlinker for activation of T cells, LAT and IDBG-239499 and ENSG00000213658 and 27040, protein kinase binding, Cell surfaces, Lat and IDBG-209436 and ENSMUSG00000030742 and 16797, BT.26847 and IDBG-638875 and ENSBTAG00000021249 and 514735
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Gene info
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Identity
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Gene
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Long gene namelinker for activation of T cells
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-07-12
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesolute carrier family 7 member 6
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Synonyms gene name
- solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesolute carrier family 7 member 7
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Synonyms gene
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Synonyms gene name
- solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesphingolipid transporter 1 (putative)
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Synonyms gene name
- spinster homolog 1 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-04-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data