LAT monoclonal antibody

• Catalog number
  11-360-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Human LAT, Clone: LAT-01
• Antigen
  LAT
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  Mouse, Other not tested
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  LAT-01
• Applications
  WB, IP, FC
• Immunogen
  Bacterially produced recombinant polypeptide _x000D_ corresponding to the entire cytoplasmic domain of human LAT.
• Format conjugation
  purified; unconjugated
• Specificity
  The antibody LAT-01 reacts with Linker for activation of T cells (LAT), a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
• Research area
  Adaptor Proteins (Human), Adaptor Proteins
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human LAT, Clone: LAT-01 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Hrdinka M, Dráber P, Stepánek O, Ormsby T, Otáhal P, Angelisová P, Brdicka T, Paces J, Horejsí V, Drbal K: PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem. 2011 Jun 3;286(22):19617-29., *Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V.: Transmembrane adaptor molecules: a new category of lymphoid-cell markers._x000D_ Blood. 2006 Jan 1;107(1):213-21. _x000D_
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  LAT   monoclonal  
• Gene symbol
  LAT, SLC7A6, SLC7A7, SPNS1
• Short name
  Anti-LAT Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to LAT
• Alternative technique
  antibodies
• Alternative to gene target
  linker for activation of T cells, LAT and IDBG-239499 and ENSG00000213658 and 27040, protein kinase binding, Cell surfaces, Lat and IDBG-209436 and ENSMUSG00000030742 and 16797, BT.26847 and IDBG-638875 and ENSBTAG00000021249 and 514735

Gene info

• Identity
  HGNC:18874
• Gene
  LAT
• Long gene name
  linker for activation of T cells
• Synonyms
  • LAT1
• Synonyms name
  • linker for activation of T cells, transmembrane adaptor
• GenBank acession
  • AF036905
• Locus
  16q13
• Discovery year
  2002-07-12
• Pubmed identfication
  • 9489702
• VEGA ID
  OTTHUMG00000131761

Gene info

• Identity
  HGNC:11064
• Gene
  SLC7A6
• Long gene name
  solute carrier family 7 member 6
• Synonyms gene name
  • solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
• Synonyms
  • y+LAT-2
  • KIAA0245
  • LAT3
  • LAT-2
• GenBank acession
  • D87432
• Locus
  16q22.1
• Discovery year
  1999-01-28
• Entrez gene record
  9057
• Pubmed identfication
  • 9878049
• RefSeq identity
  • NM_003983
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000176544

Gene info

• Identity
  HGNC:11065
• Gene
  SLC7A7
• Long gene name
  solute carrier family 7 member 7
• Synonyms gene
  • LPI
• Synonyms gene name
  • solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
• Synonyms
  • y+LAT-1
• GenBank acession
  • AF092032
• Locus
  14q11.2
• Discovery year
  1999-01-28
• Entrez gene record
  9056
• Pubmed identfication
  • 9829974
• RefSeq identity
  • NM_003982
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000028692
• Locus Specific Databases
  • LRG_695

Gene info

• Identity
  HGNC:30621
• Gene
  SPNS1
• Long gene name
  sphingolipid transporter 1 (putative)
• Synonyms gene name
  • spinster homolog 1 (Drosophila)
• Synonyms
  • HSpin1
  • nrs
  • SPINL
  • PP2030
  • SPIN1
  • LAT
  • SLC63A1
• GenBank acession
  • BC006156
• Locus
  16p11.2
• Discovery year
  2007-04-12
• Entrez gene record
  83985
• Pubmed identfication
  • 11340170
  • 12815463
• RefSeq identity
  • NM_032038
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000131762

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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