CD35 / CR1 monoclonal antibody

• Catalog number
  1P-703-T025
• Price
  Please ask
• Size
  25 assays

• Long name
  Mouse Monoclonal Antibody against Human CD35 / CR1, Clone: E11
• Antigen
  CD35
• Species reactivity
  Human (Homo sapiens), Non-Human (Homo sapiens) Primates
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  E11
• Applications
  FC, IP, WB, IHC(P), IHC(F), ICC
• Immunogen
  Acute monocytic leukemia cells and normal blood monocytes
• Format conjugation
  PE
• Specificity
  The mouse monoclonal antibody E11 recognizes CD35 (CR1), a type I glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes._x000D_ HLDA III; WS Code 204
• Research area
  CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD35 / CR1, Clone: E11 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD35 (complement receptor 1, CR1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Hogg N, Ross GD, Jones DB, Slusarenko M, Walport MJ, Lachmann PJ: Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur J Immunol. 1984 Mar;14(3):236-43., *Leukocyte Typing III., McMichael M.J. et al. (Eds.), Oxford University Press (1987); p.611.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD35   CR1   monoclonal  
• Gene symbol
  CR1
• Short name
  Anti-CD35 / CR1 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD35 / CR1
• Alternative technique
  antibodies
• Alternative to gene target
  complement component (3b/4b) receptor 1 (Knops blood group), C3BR and C4BR and CD35 and KN, CR1 and IDBG-106358 and ENSG00000203710 and 1378, complement component C3b receptor activity, Cell surfaces

Gene info

• Identity
  HGNC:2334
• Gene
  CR1
• Long gene name
  complement C3b/C4b receptor 1 (Knops blood group)
• Synonyms gene name
  • complement component (3b/4b) receptor 1, including Knops blood group system
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • complement component 3b/4b receptor 1 (Knops blood group)
• Synonyms
  • CD35
  • KN
• GenBank acession
  • Y00816
• Locus
  1q32.2
• Discovery year
  2001-06-22
• Entrez gene record
  1378
• Pubmed identfication
  • 1708809
• RefSeq identity
  • NM_000573
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000036311
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_814

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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