CD28 monoclonal antibody

• Catalog number
  1F-655-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Rat CD28, Clone: JJ319
• Antigen
  CD28 (rat)
• Species reactivity
  Rat
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  JJ319
• Applications
  FC, IP, FUNC
• Immunogen
  Mouse A20J B lymphoma cells transfected with rat CD28
• Format conjugation
  FITC
• Specificity
  The mouse monoclonal antibody JJ319 reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells._x000D_
• Research area
  CD and Related Antigens & MHC (Rodent)
• Concentration
  0.5 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Rat CD28, Clone: JJ319 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. Its analog CTLA-4, expressed on the surface of activated T cells, has higher affinity to CD80 and CD86 than CD28 and downregulates T cell activity.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD28   monoclonal  
• Gene symbol
  CD28
• Short name
  Anti-CD28 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD28 (rat)
• Alternative technique
  antibodies
• Alternative to gene target
  CD28 molecule, Tp44, CD28 and IDBG-79183 and ENSG00000178562 and 940, identical protein binding, Cell surfaces, Cd28 and IDBG-159608 and ENSMUSG00000026012 and 12487, CD28 and IDBG-643371 and ENSBTAG00000007445 and 281050

Gene info

• Identity
  HGNC:1653
• Gene
  CD28
• Long gene name
  CD28 molecule
• Synonyms gene name
  • CD28 antigen (Tp44)
• Synonyms name
  • T-cell-specific surface glycoprotein
• GenBank acession
  • J02988
• Locus
  2q33.2
• Discovery year
  1988-05-11
• Entrez gene record
  940
• Pubmed identfication
  • 1355979
• RefSeq identity
  • NM_006139
• Classification
  • CD molecules
  • Ig-like cell adhesion molecule family
  • V-set domain containing
• VEGA ID
  OTTHUMG00000132878

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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