CD273 / PD-L2 monoclonal antibody

• Catalog number
  11-178-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Human CD273 / PD-L2, Clone: 24F.10C12
• Antigen
  CD273 / PD-L2
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  24F.10C12
• Applications
  FC, IHC, FUNC
• Immunogen
  human CD273
• Format conjugation
  purified; unconjugated
• Specificity
  The mouse monoclonal antibody 24F.10C12 recognizes CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
• Research area
  CD and Related Antigens (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD273 / PD-L2, Clone: 24F.10C12 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Semnani RT, Mahapatra L, Moore V, Sanprasert V, Nutman TB: Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun. 2011 Oct;79(10):3957-65., *Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr;89(4):507-15., *Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28;116(17):3268-77.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD273   PD-L2   monoclonal  
• Gene symbol
  PDCD1LG2, MRPL37, ENPP2, KLK5, PPFIBP1, MICALL2, ZACN, PDCD1, ENPP3, GLDN
• Short name
  Anti-CD273 / PD-L2 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2a
• Alternative name
  Mouse Monoclonal to CD273 / PD-L2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:18731
• Gene
  PDCD1LG2
• Long gene name
  programmed cell death 1 ligand 2
• Synonyms
  • PD-L2
  • Btdc
  • PDL2
  • bA574F11.2
  • CD273
  • B7-DC
• Synonyms name
  • B7 dendritic cell molecule
• GenBank acession
  • AF344424
• Locus
  9p24.1
• Discovery year
  2003-11-14
• Entrez gene record
  80380
• Pubmed identfication
  • 11224527
• RefSeq identity
  • NM_025239
• Classification
  • B7 family
  • CD molecules
  • Immunoglobulin like domain containing
  • Receptor ligands
• VEGA ID
  OTTHUMG00000019504

Gene info

• Identity
  HGNC:14034
• Gene
  MRPL37
• Long gene name
  mitochondrial ribosomal protein L37
• Synonyms
  • RPML2
  • MRP-L2
• GenBank acession
  • AB051344
• Locus
  1p32.3
• Discovery year
  2001-02-28
• Entrez gene record
  51253
• Pubmed identfication
  • 10600119
• RefSeq identity
  • NM_016491
• Classification
  • Large subunit mitochondrial ribosomal proteins
  • Mitochondrial ribosomal proteins
• VEGA ID
  OTTHUMG00000008118

Gene info

• Identity
  HGNC:3357
• Gene
  ENPP2
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 2
• Synonyms gene
  • PDNP2
• Synonyms
  • ATX
  • PD-IALPHA
• Synonyms name
  • autotaxin
• GenBank acession
  • D45421
• Locus
  8q24.12
• Discovery year
  1995-08-10
• Entrez gene record
  5168
• Pubmed identfication
  • 8586446
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000164995

Gene info

• Identity
  HGNC:6366
• Gene
  KLK5
• Long gene name
  kallikrein related peptidase 5
• Synonyms gene name
  • kallikrein 5
• Synonyms
  • SCTE
  • KLK-L2
• GenBank acession
  • AF135028
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  25818
• Pubmed identfication
  • 10514489
  • 10608802
  • 16800724
  • 17012259
• RefSeq identity
  • NM_012427
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000183097

Gene info

• Identity
  HGNC:9249
• Gene
  PPFIBP1
• Long gene name
  PPFIA binding protein 1
• Synonyms gene name
  • PTPRF interacting protein, binding protein 1 (liprin beta 1)
• Synonyms
  • L2
  • hSGT2
  • hSgt2p
  • SGT2
• Synonyms name
  • liprin beta 1
• GenBank acession
  • AF034802
• Locus
  12p11.23-p11.22
• Discovery year
  1998-10-23
• Entrez gene record
  8496
• Pubmed identfication
  • 9624153
  • 11836260
• RefSeq identity
  • NM_003622
• Classification
  • Sterile alpha motif domain containing
• VEGA ID
  OTTHUMG00000169207

Gene info

• Identity
  HGNC:29672
• Gene
  MICALL2
• Long gene name
  MICAL like 2
• Synonyms
  • MGC46023
  • FLJ23471
  • MICAL-L2
  • JRAB
• Synonyms name
  • junctional Rab13-binding protein
• GenBank acession
  • BC037988
• Locus
  7p22.3
• Discovery year
  2006-11-24
• Entrez gene record
  79778
• Pubmed identfication
  • 12110185
  • 16525024
• RefSeq identity
  • NM_182924
• Classification
  • LIM domain containing
• VEGA ID
  OTTHUMG00000119021

Gene info

• Identity
  HGNC:29504
• Gene
  ZACN
• Long gene name
  zinc activated ion channel
• Synonyms gene
  • LGICZ1
• Synonyms gene name
  • ligand-gated ion channel, zinc activated 1
  • zinc activated ligand-gated ion channel
• Synonyms
  • LGICZ
  • L2
  • ZAC
  • ZAC1
• GenBank acession
  • AK122638
• Locus
  17q25.1
• Discovery year
  2006-01-31
• Entrez gene record
  353174
• Pubmed identfication
  • 12381728
  • 16083862
• RefSeq identity
  • NM_180990
• Classification
  • Zinc activated channels
• VEGA ID
  OTTHUMG00000157186

Gene info

• Identity
  HGNC:8760
• Gene
  PDCD1
• Long gene name
  programmed cell death 1
• Synonyms gene
  • SLEB2
• Synonyms gene name
  • systemic lupus erythematosus susceptibility 2
• Synonyms
  • CD279
  • PD1
  • hSLE1
  • PD-1
• GenBank acession
  • AY206416
• Locus
  2q37.3
• Discovery year
  1994-05-24
• Entrez gene record
  5133
• Pubmed identfication
  • 7851902
  • 12402038
• RefSeq identity
  • NM_005018
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000151342

Gene info

• Identity
  HGNC:3358
• Gene
  ENPP3
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 3
• Synonyms gene
  • PDNP3
• Synonyms
  • PD-IBETA
  • gp130RB13-6
  • B10
  • CD203c
• GenBank acession
  • AF005632
• Locus
  6q23.2
• Discovery year
  1995-08-10
• Entrez gene record
  5169
• Pubmed identfication
  • 9344668
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
  • CD molecules
• VEGA ID
  OTTHUMG00000016292

Gene info

• Identity
  HGNC:29514
• Gene
  GLDN
• Long gene name
  gliomedin
• Synonyms gene
  • COLM
• Synonyms gene name
  • collomin
• Synonyms
  • CRG-L2
  • CLOM
  • colmedin
  • UNC-122
• GenBank acession
  • AY358144
• Locus
  15q21.2
• Discovery year
  2004-05-18
• Entrez gene record
  342035
• Pubmed identfication
  • 16039564
  • 12642876
• RefSeq identity
  • NM_181789
• VEGA ID
  OTTHUMG00000131746

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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