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CD273 / PD-L2 monoclonal antibody

  • Catalog number
    1P-178-T100
  • Product name
    CD273 / PD-L2 monoclonal antibody
  • Size
    100 assays
  • Short name
    Anti-CD273 / PD-L2 Mab
  • Long name
    Mouse Monoclonal Antibody against Human CD273 / PD-L2, Clone: 24F.10C12
  • Antigen
    CD273 / PD-L2
  • Host
    Mouse (Mus musculus)
  • Species reactivity
    Human (Homo sapiens)
  • Negative species reactivity
    at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
  • Clonality
    Monoclonal Antibody (Mab)
  • Clone
    24F.10C12
  • Isotype
    IgG2a
  • Applications
    FC, IHC, FUNC
  • Immunogen
    human CD273
  • Format conjugation
    PE
  • Specificity
    The mouse monoclonal antibody 24F.10C12 recognizes CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
  • Research area
    CD and Related Antigens (Human)
  • Storage buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
  • Shipping and storage
    Mouse Monoclonal Antibody against Human CD273 / PD-L2, Clone: 24F.10C12 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
  • Background
    CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
  • Purity
    > 95% (by SDS-PAGE)
  • Purification method
    Purified by affinity chromatography
  • Datasheet
    Datasheet
  • References
    *Semnani RT, Mahapatra L, Moore V, Sanprasert V, Nutman TB: Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun. 2011 Oct;79(10):3957-65., *Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr;89(4):507-15., *Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28;116(17):3268-77.
  • Gene target
    CD273 / PD-L2 monoclonal
    • Gene info
    Gene info
    Gene info
    • Identity:HGNC:3357
    • Gene:ENPP2
    • Long gene name:ectonucleotide pyrophosphatase/phosphodiesterase 2
    • Synonyms:ATXPD-IALPHA
    • Discovery year:1995-08-10
    • Entrez gene record:5168
    • Pubmed identification:8586446
    • Classification:Ectonucleotide pyrophosphatase/phosphodiesterase family
    • VEGA ID:OTTHUMG00000164995
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
    Gene info
  • Gene symbol
    PDCD1LG2, MRPL37, ENPP2, KLK5, PPFIBP1, MICALL2, ZACN, PDCD1, ENPP3, GLDN
  • isotype filter
    • IgG2a
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
  • Alternative technique
    antibodies