CD261 / TRAIL-R1 / DR4 monoclonal antibody

• Catalog number
  1A-403-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human CD261 / TRAIL-R1 / DR4, Clone: DR-4-02
• Antigen
  CD261 / TRAIL-R1
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  DR-4-02
• Applications
  FC, IP, ICC, FUNC
• Immunogen
  Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
• Format conjugation
  APC
• Specificity
  The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
• Research area
  Apoptosis (Human), CD and Related Antigens (Human), Apoptosis
• Concentration
  0.1 mg/ml
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD261 / TRAIL-R1 / DR4, Clone: DR-4-02 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues._x000D_ Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36._x000D_
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD261   TRAIL-R1   DR4   monoclonal  
• Gene symbol
  TNFRSF10A, C17orf75, CDCA7L, TNFSF10, CNEP1R1, TNFRSF10B, CXCL11, PNPLA7, PCAT6
• Short name
  Anti-CD261 / TRAIL-R1 / DR4 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD261 / TRAIL-R1 / DR4
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11904
• Gene
  TNFRSF10A
• Long gene name
  TNF receptor superfamily member 10a
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10a
• Synonyms
  • DR4
  • Apo2
  • TRAILR-1
  • CD261
  • TRAILR1
• GenBank acession
  • U90875
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8797
• Pubmed identfication
  • 9311998
  • 9082980
• RefSeq identity
  • NM_003844
• Classification
  • CD molecules
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000097843

Gene info

• Identity
  HGNC:30173
• Gene
  C17orf75
• Long gene name
  chromosome 17 open reading frame 75
• Synonyms
  • NJMU-R1
  • SRI2
• Synonyms name
  • sensitization to ricin complex subunit 2
• GenBank acession
  • AB062437
• Locus
  17q11.2
• Discovery year
  2006-01-12
• Entrez gene record
  64149
• Pubmed identfication
  • 23394947
  • 29426865
• RefSeq identity
  • NM_022344
• VEGA ID
  OTTHUMG00000179585

Gene info

• Identity
  HGNC:30777
• Gene
  CDCA7L
• Long gene name
  cell division cycle associated 7 like
• Synonyms gene name
  • cell division cycle associated 7-like
• Synonyms
  • RAM2
  • R1
  • JPO2
• Locus
  7p15.3
• Discovery year
  2005-05-13
• Entrez gene record
  55536
• Pubmed identfication
  • 16829576
• RefSeq identity
  • NM_018719
• VEGA ID
  OTTHUMG00000128429

Gene info

• Identity
  HGNC:11925
• Gene
  TNFSF10
• Long gene name
  TNF superfamily member 10
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 10
• Synonyms
  • TRAIL
  • Apo-2L
  • TL2
  • CD253
• GenBank acession
  • U37518
• Locus
  3q26
• Discovery year
  1998-12-04
• Pubmed identfication
  • 8777713
  • 8663110
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000156917

Gene info

• Identity
  HGNC:26759
• Gene
  CNEP1R1
• Long gene name
  CTD nuclear envelope phosphatase 1 regulatory subunit 1
• Synonyms gene
  • C16orf69
  • TMEM188
• Synonyms gene name
  • chromosome 16 open reading frame 69
  • transmembrane protein 188
• Synonyms
  • FLJ38101
  • NEP1-R1
• Synonyms name
  • nuclear envelope phosphatase 1-regulatory subunit 1
• GenBank acession
  • AK095420
• Locus
  16q12.1
• Discovery year
  2006-04-07
• Entrez gene record
  255919
• Pubmed identfication
  • 22134922
• RefSeq identity
  • NM_153261
• VEGA ID
  OTTHUMG00000173447

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

Gene info

• Identity
  HGNC:10638
• Gene
  CXCL11
• Long gene name
  C-X-C motif chemokine ligand 11
• Synonyms gene
  • SCYB9B
  • SCYB11
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • chemokine (C-X-C motif) ligand 11
• Synonyms
  • H174
  • b-R1
  • I-TAC
  • IP-9
• GenBank acession
  • U66096
• Locus
  4q21.1
• Discovery year
  1998-06-23
• Entrez gene record
  6373
• Pubmed identfication
  • 9730616
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130101

Gene info

• Identity
  HGNC:24768
• Gene
  PNPLA7
• Long gene name
  patatin like phospholipase domain containing 7
• Synonyms gene
  • C9orf111
• Synonyms gene name
  • chromosome 9 open reading frame 111
  • patatin-like phospholipase domain containing 7
• Synonyms
  • FLJ43070
  • FLJ31318
  • FLJ44279
  • RP11-48C7.2
  • NTEL1
  • NTE-R1
• GenBank acession
  • AK126267
• Locus
  9q34.3
• Discovery year
  2004-03-25
• Entrez gene record
  375775
• Pubmed identfication
  • 16799181
  • 12640454
  • 19029121
• RefSeq identity
  • NM_152286
• Classification
  • Patatin like phospholipase domain containing
• VEGA ID
  OTTHUMG00000020990

Gene info

• Identity
  HGNC:43714
• Gene
  PCAT6
• Long gene name
  prostate cancer associated transcript 6
• Synonyms gene
  • KDM5B-AS1
• Synonyms gene name
  • KDM5B antisense RNA 1 (head to head)
  • prostate cancer associated transcript 6 (non-protein coding)
• Synonyms
  • ncRNA-a2
  • PCAN-R1
  • KDM5BAS1
  • onco-lncRNA-96
• Synonyms name
  • prostate cancer-associated noncoding RNA 1
• GenBank acession
  • BI962506
  • AI806248
• Locus
  1q32.1
• Discovery year
  2012-02-02
• Entrez gene record
  100506696
• Pubmed identfication
  • 20887892
  • 23728290
• RefSeq identity
  • NR_046325
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000041399

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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