NFkB Inducing Kinase NIK

Conjugation

Alexa Fluor 350
Note

For research use only.
Gene

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory

Identity

HGNC:6866
Gene

MAP4K4
Long gene name

mitogen-activated protein kinase kinase kinase kinase 4
Synonyms
- HGK
- NIK
- FLH21957
Synonyms name
- HPK/GCK-like kinase
- hepatocyte progenitor kinase-like/germinal center kinase-like kinase
GenBank acession
- AF096300
Locus

2q11.2
Discovery year

1999-09-07
Entrez gene record

9448
Pubmed identfication
- 9890973
- 9734811
- 9135144
RefSeq identity
- NM_004834
Classification
- Mitogen-activated protein kinase kinase kinase kinases
VEGA ID

OTTHUMG00000155394