Recombinant Rat Cadherin-8 / CDH8 Protein (His tag) 10µg

• Catalog number
  PKSR030268-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  CDH8
• Activity
  NA
• Sequence
  Met1-Met621
• Fusion tag
  C-His
• Accession
  NP_445845.2
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 85 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  66.5 kDa
• AP Mol Mass
  75-85 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I  cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I  transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.
• Technical Data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Cadherin-8   CDH8   Protein   His   tag   10µg  
• Gene symbol
  CDH8, CDH8-AS1
• Short name
  Recombinant Cadherin-8 / CDH8 Protein (His tag) 10µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat Cadherin-8 / cadherin 8, type 2 Protein (histidine detection labelled) 10µg
• Alternative technique
  rec
• Alternative to gene target
  cadherin 8, type 2, Nbla04261, CDH8 and IDBG-34762 and ENSG00000150394 and 1006, calcium ion binding, Plasma membranes, Cdh8 and IDBG-184746 and ENSMUSG00000036510 and 12564, BT.37690 and IDBG-633020 and ENSBTAG00000022783 and 521039

Gene info

• Identity
  HGNC:1767
• Gene
  CDH8
• Long gene name
  cadherin 8
• Synonyms gene name
  • cadherin 8, type 2
• GenBank acession
  • L34060
• Locus
  16q21
• Discovery year
  1997-02-10
• Entrez gene record
  1006
• Pubmed identfication
  • 9615235
  • 2059658
• RefSeq identity
  • NM_001796
• Classification
  • Type II classical cadherins
• VEGA ID
  OTTHUMG00000137493

Gene info

• Identity
  HGNC:55399
• Gene
  CDH8-AS1
• Long gene name
  CDH8 antisense RNA 1
• Locus
  16q21
• Discovery year
  2020-12-21
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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