Recombinant Human Cadherin-8 / CDH8 Protein (His tag) 10µg
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Catalog number
PKSH031835-10µg
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Price
Please ask
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Size
10µg
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Synonym
Nbla04261
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Activity
NA
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Sequence
Met 1-Met 621
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Fusion tag
C-His
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Accession
NP_001787.2
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
>90 % as determined by SDS-PAGE
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Endotoxin
<1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
66.6 kDa
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AP Mol Mass
85-90 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Reconstitution
Please refer to it for detailed information.
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Background
Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
CDH8, CDH8-AS1
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Short name
Recombinant Cadherin-8 / CDH8 Protein (His tag) 10µg
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
His
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Cadherin-8 / cadherin 8, type 2 Protein (histidine detection labelled) 10µg
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Alternative technique
rec
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Alternative to gene target
cadherin 8, type 2, Nbla04261, CDH8 and IDBG-34762 and ENSG00000150394 and 1006, calcium ion binding, Plasma membranes, Cdh8 and IDBG-184746 and ENSMUSG00000036510 and 12564, BT.37690 and IDBG-633020 and ENSBTAG00000022783 and 521039
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Gene info
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Identity
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Gene
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Long gene name
cadherin 8
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Synonyms gene name
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GenBank acession
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Locus
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Discovery year
1997-02-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Type II classical cadherins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
CDH8 antisense RNA 1
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Locus
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Discovery year
2020-12-21
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Classification
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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