Recombinant Mouse PTPN2 / TC-PTP Protein (aa 2-314, His tag) 100µg

• Catalog number
  PKSM040482-100µg
• Price
  Please ask
• Size
  100µg

• Activity
  Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 15 nmoles/min/μg.
• Synonym
  AI325124;Ptpt;TC-PTP
• Sequence
  Ser 2-Asn 314
• Fusion tag
  N-His
• Accession
  Q06180-1
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  38.7 kDa
• AP Mol Mass
  42 kDa
• Formulation
  Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 20% gly, 0.1mM TCEP
• Background
  Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  PTPN2   TC-PTP   Protein   2-314   His   tag   100µg  
• Gene symbol
  PTPN2, PTPN13, PTPRU, MT-TC, PTPRK, CD55, PTPRO, PTPRR, ACP1, REG1A
• Short name
  Recombinant Mouse PTPN2 / TC-PTP Protein (aa 2-314, His tag) 100µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse PTPN2 / TC-PTP Protein (aa 2-314, histidine detection labelled) 100µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:9650
• Gene
  PTPN2
• Long gene name
  protein tyrosine phosphatase non-receptor type 2
• Synonyms gene
  • PTPT
• Synonyms
  • TCELLPTP
  • TC-PTP
  • TCPTP
• GenBank acession
  • M25393
• Locus
  18p11.21
• Discovery year
  1991-09-13
• Entrez gene record
  5771
• Pubmed identfication
  • 2164224
• RefSeq identity
  • NM_002828
  • NM_080422
  • NM_080423
• Classification
  • Protein tyrosine phosphatases non-receptor type
• VEGA ID
  OTTHUMG00000131702

Gene info

• Identity
  HGNC:9646
• Gene
  PTPN13
• Long gene name
  protein tyrosine phosphatase non-receptor type 13
• Synonyms gene name
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
• Synonyms
  • PTP1E
  • PTP-BAS
  • PTPL1
  • PTP-BL
• Synonyms name
  • APO-1/CD95 (Fas)-associated phosphatase
• Locus
  4q21.3
• Discovery year
  1995-02-17
• Pubmed identfication
  • 8287977
• Classification
  • Protein tyrosine phosphatases non-receptor type
  • PDZ domain containing
  • FERM domain containing
• VEGA ID
  OTTHUMG00000160968

Gene info

• Identity
  HGNC:9683
• Gene
  PTPRU
• Long gene name
  protein tyrosine phosphatase receptor type U
• Synonyms
  • PTPRO
  • hPTP-J
  • PCP-2
  • FMI
  • PTP
• Synonyms name
  • pi R-PTP-Psi
• GenBank acession
  • U71075
• Locus
  1p35.3
• Discovery year
  1999-10-28
• Entrez gene record
  10076
• Pubmed identfication
  • 8700514
  • 9434160
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000003699

Gene info

• Identity
  HGNC:7477
• Gene
  MT-TC
• Long gene name
  mitochondrially encoded tRNA-Cys (UGU/C)
• Synonyms gene
  • MTTC
• Synonyms gene name
  • tRNA cysteine
  • mitochondrially encoded tRNA cysteine
• Synonyms
  • trnC
• Locus
  mitochondria
• Discovery year
  1989-10-12
• Entrez gene record
  4511
• Pubmed identfication
  • 7219534
• Classification
  • Mitochondrially encoded transfer RNAs

Gene info

• Identity
  HGNC:9674
• Gene
  PTPRK
• Long gene name
  protein tyrosine phosphatase receptor type K
• Synonyms
  • R-PTP-kappa
• GenBank acession
  • L77886
• Locus
  6q22.33
• Discovery year
  1998-02-09
• Entrez gene record
  5796
• Pubmed identfication
  • 9047348
  • 8663237
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000015536

Gene info

• Identity
  HGNC:2665
• Gene
  CD55
• Long gene name
  CD55 molecule (Cromer blood group)
• Synonyms gene
  • DAF
• Synonyms gene name
  • decay accelerating factor for complement (CD55, Cromer blood group system)
  • CD55 molecule, decay accelerating factor for complement (Cromer blood group)
• Synonyms
  • CR
  • TC
  • CROM
• GenBank acession
  • BC001288
• Locus
  1q32.2
• Discovery year
  2001-06-22
• Entrez gene record
  1604
• RefSeq identity
  • NM_000574
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000036255
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • CD55base: Mutation registry for Decay-accelerating factor (CD55) deficiency (previously known as DAFbase)
  • LRG_127

Gene info

• Identity
  HGNC:9678
• Gene
  PTPRO
• Long gene name
  protein tyrosine phosphatase receptor type O
• Synonyms
  • PTPU2
  • GLEPP1
  • PTP-U2
  • PTP-oc
  • NPHS6
• Synonyms name
  • osteoclastic transmembrane protein-tyrosine phosphatase
• GenBank acession
  • U20489
• Locus
  12p12.3
• Discovery year
  1995-02-22
• Entrez gene record
  5800
• Pubmed identfication
  • 7519601
  • 7665166
  • 21722858
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000168786

Gene info

• Identity
  HGNC:9680
• Gene
  PTPRR
• Long gene name
  protein tyrosine phosphatase receptor type R
• Synonyms gene
  • PTPRQ
• Synonyms
  • PTPBR7
  • PTP-SL
  • EC-PTP
  • PCPTP1
• GenBank acession
  • D64053
• Locus
  12q15
• Discovery year
  1999-10-28
• Entrez gene record
  5801
• Pubmed identfication
  • 7557444
  • 10393441
• RefSeq identity
  • NM_002849
• Classification
  • Protein tyrosine phosphatases receptor type
• VEGA ID
  OTTHUMG00000169502

Gene info

• Identity
  HGNC:122
• Gene
  ACP1
• Long gene name
  acid phosphatase 1
• Synonyms gene name
  • acid phosphatase 1, soluble
• Synonyms
  • HAAP
  • LMW-PTP
  • LMWPTP
• Synonyms name
  • acid phosphatase of erythrocyte
  • low molecular weight phosphotyrosine protein phosphatase
  • red cell acid phosphatase
• GenBank acession
  • M87546
• Locus
  2p25.3
• Discovery year
  1986-01-01
• Entrez gene record
  52
• Pubmed identfication
  • 457131
  • 1587862
  • 8586411
• RefSeq identity
  • NM_004300
• Classification
  • Acid phosphatases
  • Class II Cys-based phosphatases
• VEGA ID
  OTTHUMG00000086933

Gene info

• Identity
  HGNC:9951
• Gene
  REG1A
• Long gene name
  regenerating family member 1 alpha
• Synonyms gene
  • REG
• Synonyms gene name
  • regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
• Synonyms
  • PSP
  • PTP
  • PSPS
  • PSPS1
• Synonyms name
  • pancreatic stone protein
  • pancreatic thread protein
• Locus
  2p12
• Discovery year
  1992-06-05
• Entrez gene record
  5967
• Pubmed identfication
  • 2332435
  • 8333731
• RefSeq identity
  • NM_002909
• Classification
  • C-type lectin domain containing
• VEGA ID
  OTTHUMG00000130016

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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