Recombinant Mouse GPNMB / Osteoactivin Protein (His tag)

• Catalog number
  PKSM040661-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  DC-HIL;Dchil;ipd
• Activity
  NA
• Sequence
  Met1-Asn502
• Fusion tag
  C-His
• Accession
  Q99P91
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  54.9 kDa
• AP Mol Mass
  96 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  GPNMB   Osteoactivin   Protein   His   tag  
• Gene symbol
  GPNMB
• Short name
  Recombinant Mouse GPNMB / Osteoactivin Protein (His tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse glycoprotein (transmembrane) nmb / Osteoactivin Protein (histidine detection labelled)
• Alternative technique
  rec, murine
• Alternative to gene target
  glycoprotein (transmembrane) nmb, HGFIN and NMB, GPNMB and IDBG-9627 and ENSG00000136235 and 10457, heparin binding, Plasma membranes, Gpnmb and IDBG-146080 and ENSMUSG00000029816 and 93695, BT.99652 and IDBG-630320 and ENSBTAG00000000604 and 509600

Gene info

• Identity
  HGNC:4462
• Gene
  GPNMB
• Long gene name
  glycoprotein nmb
• Synonyms gene name
  • glycoprotein (transmembrane) nmb
• Synonyms
  • NMB
  • HGFIN
• Synonyms name
  • transmembrane glycoprotein
  • glycoprotein NMB
  • glycoprotein nmb-like protein
  • osteoactivin
  • hematopoietic growth factor inducible neurokinin-1
  • glycoprotein nonmetastatic melanoma protein B
• GenBank acession
  • X76534
• Locus
  7p15.3
• Discovery year
  1999-10-26
• Entrez gene record
  10457
• Pubmed identfication
  • 7814155
• RefSeq identity
  • NM_001005340
• VEGA ID
  OTTHUMG00000022811

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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