Recombinant Human GPNMB / Osteoactivin Protein (Fc tag)
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Catalog number
PKSH031160-50µg
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Price
Please ask
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Size
50µg
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Synonym
HGFIN;NMB;Osteoactivin
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Activity
NA
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Sequence
Met1-Pro474
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Fusion tag
C-Fc
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Accession
Q14956-2
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞95 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
77.8 kDa
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AP Mol Mass
114 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteoclasts, macrophages, dendritic cells, and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. The early-phase upregulation of Osteoactivin expression in the tubular epithelium in response to renal injury might play a role in triggering renal interstitial fibrosis via activation of matrix metalloproteinase expression and collagen remodeling in rats. Osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
GPNMB
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Short name
Recombinant GPNMB / Osteoactivin Protein (Fc tag)
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Human, Humans
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Alternative name
Rec. H. sapiens glycoprotein (transmembrane) nmb / Osteoactivin Protein (fragment c detection labelled)
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Alternative technique
rec
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Alternative to gene target
glycoprotein (transmembrane) nmb, HGFIN and NMB, GPNMB and IDBG-9627 and ENSG00000136235 and 10457, heparin binding, Plasma membranes, Gpnmb and IDBG-146080 and ENSMUSG00000029816 and 93695, BT.99652 and IDBG-630320 and ENSBTAG00000000604 and 509600
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Gene info
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Identity
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Gene
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Long gene name
glycoprotein nmb
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Synonyms gene name
- glycoprotein (transmembrane) nmb
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1999-10-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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