Recombinant Mouse CD64 / FCGR1 Protein (His tag)

• Catalog number
  PKSM040932-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  AI323638;AV092959;CD64;FcgammaRI;IGGHAFC
• Activity
  Measured by its binding ability in a functional ELISA. Immobilized mouse CD64-His at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.07-0.17 μg/ml.
• Sequence
  Met 1-Pro 297
• Fusion tag
  C-His
• Accession
  NP_034316.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  32 kDa
• AP Mol Mass
  45-50 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD64   FCGR1   Protein   His   tag  
• Gene symbol
  FCGR1A
• Short name
  Recombinant Mouse CD64 / FCGR1 Protein (His tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse CD64 / FCGR1 Protein (histidine detection labelled)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:3613
• Gene
  FCGR1A
• Long gene name
  Fc gamma receptor Ia
• Synonyms gene name
  • Fc fragment of IgG, high affinity Ia, receptor for (CD64)
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc fragment of IgG receptor Ia
• Synonyms
  • CD64
  • CD64A
  • FcgammaRI
  • FcgammaRIa
  • FCG1
  • FCGR1
• Synonyms name
  • Fc gamma RI
• GenBank acession
  • BC032634
• Locus
  1q21.2
• Discovery year
  1992-12-03
• Entrez gene record
  2209
• Pubmed identfication
  • 8697799
  • 9763663
• RefSeq identity
  • NM_000566
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000012089
• Locus Specific Databases
  • FCGR1Abase: Mutation registry for CD64 deficiency
  • LRG_59

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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