Recombinant Mouse C-X-C Motif Chemokine 12/CXCL12/SDF-1 αProtein 50µg
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Catalog numberPKSM040993-50µg
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PricePlease ask
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Size50µg
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ActivityNA
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SynonymCxcl12;Stromal cell-derived factor 1;SDF-1;12-O-tetradecanoylphorbol 13-acetate repressed protein 1;TPAR1;C-X-C motif chemokine 12;Pre-B cell growth-stimulating factor;PBSF;Thymic lymphoma cell-stimulating factor;TLSF;Sdf1
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SequenceLys22-Lys89
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Fusion tagNA
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AccessionP40224
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Expressed HostE.coli
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ShippingThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity＞95% as determined by reducing SDS-PAGE.
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Stability and StorageLyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass8.1 kDa
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AP Mol Mass10 kDa
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FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
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BackgroundMouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.
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DescriptionChemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Elabscience in 1.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolCXCL12, SMC4, PFDN4, FOS, JUN, TAC4, MYB, PCK1, ROS1
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Short nameRecombinant Mouse C-X-C Motif Chemokine 12/CXCL12/SDF-1 αProtein 50µg
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TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Hostmouse
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SpeciesMouse, Mouses
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Alternative nameRec. Mouse C-X-C Motif Chemokine 12/chemokine (C-X-C motif) ligand 12/SDF-1 αProtein 50µg
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Alternative techniquerec, murine
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Alternative to gene targetchemokine (C-X-C motif) ligand 12, IRH and PBSF and SCYB12 and SDF1 and TLSF and TPAR1, CXCL12 and IDBG-71595 and ENSG00000107562 and 6387, CXCR chemokine receptor binding, Extracellular, Cxcl12 and IDBG-180998 and ENSMUSG00000061353 and 20315, CXCL12 and IDBG-632037 and ENSBTAG00000005077 and 613811
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Gene info
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Identity
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Gene
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Long gene nameC-X-C motif chemokine ligand 12
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Synonyms gene
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Synonyms gene name
- stromal cell-derived factor 1
- chemokine (C-X-C motif) ligand 12
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-11-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Chemokine ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namestructural maintenance of chromosomes 4
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Synonyms gene
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Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-22
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Entrez gene record
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Pubmed identfication
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Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprefoldin subunit 4
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Synonyms gene name
- prefoldin 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Prefoldin subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFos proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-fos FBJ murine osteosarcoma viral oncogene homolog
- FBJ murine osteosarcoma viral oncogene homolog
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fos transcription factor family
- Basic leucine zipper proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameJun proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-jun avian sarcoma virus 17 oncogene homolog
- jun oncogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1988-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic leucine zipper proteins
- Jun transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametachykinin precursor 4
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Synonyms gene name
- tachykinin 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-10-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tachykinin precursors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMYB proto-oncogene, transcription factor
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Synonyms gene name
- v-myb avian myeloblastosis viral oncogene homolog
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Synonyms
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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Classification
- Myb/SANT domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namephosphoenolpyruvate carboxykinase 1
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Synonyms gene name
- phosphoenolpyruvate carboxykinase 1 (soluble)
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Synonyms
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Locus
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Discovery year1990-09-10
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameROS proto-oncogene 1, receptor tyrosine kinase
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Synonyms gene name
- v-ros avian UR2 sarcoma virus oncogene homolog 1
- v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
- c-ros oncogene 1 , receptor tyrosine kinase
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- Fibronectin type III domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
