Recombinant Human C-X-C Motif Chemokine 4/CXCL4/PF4 Protein(C-6His) 50µg
-
Catalog number
PKSH032302-50µg
-
Price
Please ask
-
Size
50µg
-
-
Synonym
Platelet Factor 4; PF-4; C-X-C Motif Chemokine 4; Iroplact; Oncostatin-A; PF4; CXCL4; SCYB4
-
Activity
NA
-
Sequence
Glu32-Ser101
-
Fusion tag
C-6His
-
Accession
P02776
-
Expressed Host
Human cells
-
Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
-
Purity
＞95% as determined by reducing SDS-PAGE.
-
Endotoxin
＜1.0 EU per µg as determined by LAL test.
-
Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
-
Mol Mass
8.5 kDa
-
AP Mol Mass
10-14 kDa
-
Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
-
Reconstitution
Please refer to it for detailed information.
-
Background
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.
-
-
-
Description
Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Elabscience in 1.
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
PF4, SMC4, MYB, PCK1, SFTPC, VCX3B, MAF, RFX1, EGR4
-
Short name
Recombinant C-X-C Motif Chemokine 4/CXCL4/PF4 Protein(C-6His) 50µg
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Species
Human, Humans
-
Alternative name
Rec. H. sapiens C-X-C Motif Chemokine 4/CXCL4/platelet factor 4 Protein(C-6His) 50µg
-
Alternative technique
rec
-
Alternative to gene target
platelet factor 4, CXCL4 and PF-4 and SCYB4, PF4 and IDBG-24097 and ENSG00000163737 and 5196, CXCR3 chemokine receptor binding, Extracellular
-
Gene info
-
Identity
-
Gene
-
Long gene name
platelet factor 4
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
2001-06-22
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
Gene info
Gene info
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
surfactant protein C
-
Synonyms gene
-
Synonyms gene name
- surfactant, pulmonary-associated protein C
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year
1988-05-11
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- BRICHOS domain containing
-
VEGA ID
Gene info
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
regulatory factor X1
-
Synonyms gene name
- regulatory factor X, 1 (influences HLA class II expression)
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year
1991-11-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Regulatory factor X family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene name
early growth response 4
-
Synonyms
-
Locus
-
Discovery year
1992-07-27
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
-
VEGA ID
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
