Recombinant Human Serum Amyloid P-Component/Pentraxin 2/SAP Protein(C-6His)

• Catalog number
  PKSH033050-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Serum Amyloid P-Component; SAP; 9.5S Alpha-1-Glycoprotein; APCS; PTX2
• Activity
  NA
• Sequence
  His20-Val223
• Fusion tag
  C-6His
• Accession
  P02743
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  24.2 kDa
• AP Mol Mass
  30 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Background
  Serum Amyoid P Component (SAP) is a monomeric 25 kDa secreted serum glycoprotein that belongs to the pentraxins family. The members of pentaxin superfamily be characterised by calcium dependent ligand binding and distinctive flattened β-jellyroll structure similar to that of the legume lectins. SAP is a non-fibrillar component, it can interact with DNA and histones. It regulates the solubility of amyloid fibrils and protects them from degradation by proteolytic enzymes and phagocytic cells. SAP scavenge nuclear material released from damaged circulating cells. It has been proposed that SAP may function as an opsonin for a variety of ligands including autoantigens, apoptotic cells, chromatin and micro-organisms.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants, Sera
• Description
  Azide Free Serum for cell culture FBS fetal bovine serum. Filtered serum for sterility. The polyclonal serum contains no red or white blood cells or clotting factors; it is the blood plasma not including the fibrinogens. Serum includes all proteins and antibodies not used in blood clotting (coagulation) and all the electrolytes, antibodies, antigens, hormones, and any exogenous substances like drugs and microorganisms. Plasmas on request.
• About
  Serum should be stored at +5°C

• Gene target
  Amyloid   P-Component/Pentraxin   2/SAP   Protein   C-6His  
• Gene symbol
  GM2A, PTPRH, APCS, DLG1, DLG4, SH2D1A, DLG3
• Short name
  Recombinant Serum Amyloid P-Component/Pentraxin 2/SAP Protein(C-6His)
• Technique
  Recombinant, serum, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens blood serum Amyloid P-Component/Pentraxin 2/SAP Protein(C-6His)
• Alternative technique
  rec, sera
• Tissue
  serum

Gene info

• Identity
  HGNC:4367
• Gene
  GM2A
• Long gene name
  GM2 ganglioside activator
• Synonyms gene name
  • GM2 ganglioside activator protein
• Synonyms
  • SAP-3
• Synonyms name
  • cerebroside sulfate activator protein
  • sphingolipid activator protein 3
• Locus
  5q33.1
• Discovery year
  1986-01-01
• Entrez gene record
  2760
• Pubmed identfication
  • 115863
  • 1915857
• RefSeq identity
  • NM_000405
• VEGA ID
  OTTHUMG00000130124
• Locus Specific Databases
  • GM2A Locus Database

Gene info

• Identity
  HGNC:9672
• Gene
  PTPRH
• Long gene name
  protein tyrosine phosphatase receptor type H
• Synonyms
  • SAP-1
• Locus
  19q13.42
• Discovery year
  1994-09-14
• Entrez gene record
  5794
• Pubmed identfication
  • 8294459
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000180701

Gene info

• Identity
  HGNC:584
• Gene
  APCS
• Long gene name
  amyloid P component, serum
• Synonyms
  • SAP
  • PTX2
  • MGC88159
• Synonyms name
  • pentraxin-related
  • 9.5S alpha-1-glycoprotein
  • pentraxin-2
• Locus
  1q23.2
• Discovery year
  2001-06-22
• Entrez gene record
  325
• Pubmed identfication
  • 2987268
• RefSeq identity
  • NM_001639
• Classification
  • Short pentraxins
• VEGA ID
  OTTHUMG00000022741

Gene info

• Identity
  HGNC:2900
• Gene
  DLG1
• Long gene name
  discs large MAGUK scaffold protein 1
• Synonyms gene name
  • discs, large homolog 1 (Drosophila)
  • discs large homolog 1, scribble cell polarity complex component
• Synonyms
  • SAP97
  • SAP-97
  • hdlg
  • DLGH1
  • dJ1061C18.1.1
• Synonyms name
  • discs large homolog 1
  • presynaptic protein SAP97
  • synapse-associated protein 97
• GenBank acession
  • U13897
• Locus
  3q29
• Discovery year
  1995-05-04
• Entrez gene record
  1739
• Pubmed identfication
  • 7937897
  • 8825652
• RefSeq identity
  • NM_004087
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • MicroRNA protein coding host genes
  • Scribble complex
• VEGA ID
  OTTHUMG00000047972

Gene info

• Identity
  HGNC:2903
• Gene
  DLG4
• Long gene name
  discs large MAGUK scaffold protein 4
• Synonyms gene name
  • discs, large homolog 4 (Drosophila)
  • discs large homolog 4
• Synonyms
  • PSD-95
  • PSD95
  • SAP90
  • SAP-90
• GenBank acession
  • U83192
• Locus
  17p13.1
• Discovery year
  1995-11-07
• Entrez gene record
  1742
• Pubmed identfication
  • 9286702
• RefSeq identity
  • NM_001365
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000134327

Gene info

• Identity
  HGNC:10820
• Gene
  SH2D1A
• Long gene name
  SH2 domain containing 1A
• Synonyms gene
  • IMD5
  • LYP
• Synonyms gene name
  • lymphoproliferative syndrome
  • SH2 domain protein 1A
• Synonyms
  • XLP
  • MTCP1
  • DSHP
  • XLPD
  • EBVS
  • SAP
• Synonyms name
  • Duncan's disease
• GenBank acession
  • AL023657
• Locus
  Xq25
• Discovery year
  1989-06-30
• Entrez gene record
  4068
• Pubmed identfication
  • 9771704
  • 9774102
• RefSeq identity
  • NM_002351
• Classification
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000022344
• Locus Specific Databases
  • SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP)
  • LRG_106

Gene info

• Identity
  HGNC:2902
• Gene
  DLG3
• Long gene name
  discs large MAGUK scaffold protein 3
• Synonyms gene name
  • discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
  • discs, large homolog 3 (Drosophila)
  • discs large homolog 3
• Synonyms
  • NE-Dlg
  • SAP102
  • SAP-102
  • NEDLG
  • KIAA1232
  • MRX90
  • PPP1R82
• Synonyms name
  • neuroendocrine-dlg
  • protein phosphatase 1, regulatory subunit 82
  • synapse associated protein 102
• GenBank acession
  • U49089
• Locus
  Xq13.1
• Discovery year
  1997-04-21
• Entrez gene record
  1741
• Pubmed identfication
  • 9598320
• RefSeq identity
  • NM_021120
• Classification
  • Membrane associated guanylate kinases
  • PDZ domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000021778
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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