Recombinant Human Pro-Neuregulin-1/NRG1-‑β1/HRG1-‑β1 Protein(Met1-Lys246, N-6His)
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Catalog number
PKSH032940-10µg
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Price
Please ask
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Size
10µg
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Synonym
Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1 ECD;EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;
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Activity
NA
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Sequence
Met1-Lys246
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Fusion tag
N-6His
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Accession
Q02297-6
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Expressed Host
E.coli
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
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Mol Mass
29.0 kDa
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AP Mol Mass
38 kDa
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Formulation
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
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Background
neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
NRG1-IT1, NRG1, NRG1-IT3, SLC48A1
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Short name
Recombinant Pro-Neuregulin-1/NRG1-‑β1/HRG1-‑β1 Protein(Met1-Lys246, N-6His)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens L-proline-Neuregulin-1/neuregulin 1-‑β1/HRG1-‑β1 Protein(Met1-Lys246, N-6His)
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Alternative technique
rec
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Alternative to gene target
neuregulin 1, ARIA and GGF and GGF2 and HGL and HRG and HRG1 and HRGA and MST131 and MSTP131 and NDF and NRG1-IT2 and SMDF, NRG1 and IDBG-16182 and ENSG00000157168 and 3084, ErbB-3 class receptor binding, nuclei, Nrg1 and IDBG-146861 and ENSMUSG00000062991 and 211323, NRG1 and IDBG-628923 and ENSBTAG00000004150 and 281361
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Gene info
Gene info
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Identity
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Gene
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Long gene name
neuregulin 1
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Synonyms gene
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Synonyms gene name
- NRG1 intronic transcript 2 (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year
1999-03-19
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Entrez gene record
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Pubmed identfication
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Classification
- I-set domain containing
- Neuregulins
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VEGA ID
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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