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Target antigen
NRG1
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat
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Analyses
WB
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Immunogen
E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the NRG1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The NRG1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
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Related articles
1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B.Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Go, R. C. P., Perry, R. T., Wiener, H., Bassett, S. S., Blacker, D., Devlin, B., Sweet, R. A. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am. J. Med. Genet. 139B: 28-32, 2005.
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Gene Name
NRG1
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Protein Name
Pro-neuregulin-1, membrane-bound isoform
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Gene Full Name
neuregulin 1
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Synonyms
Acetylcholine receptor inducing activity antibody|Acetylcholine receptor-inducing activity antibody|Acetylcholine receptor-inducing activity, CHICK, homolog of antibody|ARIA antibody|Breast cancer cell differentiation factor p45 antibody|ERBB2 p185 activator antibody|GGF 2 antibody|GGF antibody|GGF2 antibody|Glial growth factor antibody|Heregulin alpha antibody|Heregulin antibody|heregulin, alpha (45kD, ERBB2 p185-activator) antibody|HGL antibody|HRG 1 antibody|HRG antibody|HRG1 antibody|HRGA antibody|MST131 antibody|NDF antibody|Neu differentiation factor antibody|Neuregulin 1 antibody|neuregulin 1 type IV beta 1a antibody|neuregulin 1 type IV beta 3 antibody|Neuregulin-1 antibody|Neuregulin1 antibody|NRG 1 antibody|nrg1 antibody|NRG1-IT2 antibody|NRG1_HUMAN antibody|OTTHUMP00000225398 antibody|OTTHUMP00000225419 antibody|OTTHUMP00000225420 antibody|OTTHUMP00000225421 antibody|OTTHUMP00000225422 antibody|OTTHUMP00000225477 antibody|OTTHUMP00000225545 antibody|OTTHUMP00000230603 antibody|OTTHUMP00000230605 antibody|Pro neuregulin 1 antibody|Pro NRG1 antibody|pro-neuregulin-1, membrane-bound isoform antibody|Pro-NRG1 antibody|Proneuregulin 1 antibody|ProNRG1 antibody|Sensory and motor neuron derived factor antibody|Sensory and motor neuron-derived factor antibody|SMDF antibody
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Uniprot ID
Q02297
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Entrez GeneID
3084
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
