Recombinant Human PAPS Synthase 1/PAPSS1 Protein(C-6His) 50µg

• Catalog number
  PKSH032852-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1;PAPS synthase 1;PAPSS 1;Sulfurylase kinase 1;SK 1;ATPSK1; PAPSS
• Activity
  NA
• Sequence
  Met1-Ala624
• Fusion tag
  C-6His
• Accession
  Q96A00
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
• Mol Mass
  71.9 kDa
• AP Mol Mass
  22 kDa
• Formulation
  Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,20% glycerol,pH 8.0.
• Reconstitution
  Please refer to it for detailed information.
• Background
  PAPSS1 is a bifunctional enzyme with both ATP sulfurylase and APS kinase activity. In the N-terminal section, it belongs to the APS kinase family; while the C-terminal section belongs to the sulfate adenylyltransferase family. PAPSS1 can be inhibited by chlorate, and is expressed in many tissues, such as high endothelial venules (HEV) cells and in cartilage. PAPSS1 mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate. In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. PAPSS1 also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  PAPS   Synthase   1/PAPSS1   Protein   C-6His   50µg  
• Gene symbol
  PAPSS1
• Short name
  Recombinant PAPS Synthase 1/PAPSS1 Protein(C-6His) 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens PAPS Synthase 1/PAPSS1 Protein(C-6His) 50µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:8603
• Gene
  PAPSS1
• Long gene name
  3'-phosphoadenosine 5'-phosphosulfate synthase 1
• Synonyms
  • ATPSK1
  • PAPSS
• Synonyms name
  • sulfate adenylyltransferase
  • adenylyl-sulfate kinase
• GenBank acession
  • Y10387
• Locus
  4q25
• Discovery year
  1999-01-29
• Entrez gene record
  9061
• Pubmed identfication
  • 9576487
  • 9771708
• VEGA ID
  OTTHUMG00000131210

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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