Recombinant Human Interleukin-25/IL-25 Protein(C-6His)

• Catalog number
  PKSH032634-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Interleukin-25; IL-25; Interleukin-17E; IL-17E; IL25; IL17E
• Activity
  NA
• Sequence
  Tyr33-Gly177
• Fusion tag
  C-6His
• Accession
  Q9H293
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  16.7 kDa
• AP Mol Mass
  20-26 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl 1mM EDTA,pH8.0.
• Background
  Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Interleukin-25/IL-25   Protein   C-6His  
• Gene symbol
  IL25, MYDGF, SNORD116-25, ZNF211, SNORD114-25, SNORD115-25, ERVW-25, IGKV3D-25, RNVU1-25, IGLV3-25
• Short name
  Recombinant Interleukin-25/IL-25 Protein(C-6His)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Interleukin-25/Interleukin-25 Protein(C-6His)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:13765
• Gene
  IL25
• Long gene name
  interleukin 25
• Synonyms gene
  • IL17E
• Synonyms gene name
  • interleukin 17E
• Synonyms
  • IL-25
  • IL-17E
• GenBank acession
  • AF305200
• Locus
  14q11.2
• Discovery year
  2001-01-26
• Pubmed identfication
  • 11058597
  • 11754819
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000028749

Gene info

• Identity
  HGNC:16948
• Gene
  MYDGF
• Long gene name
  myeloid derived growth factor
• Synonyms gene
  • IL27
  • IL27w
  • C19orf10
• Synonyms gene name
  • interleukin 27 working designation
  • chromosome 19 open reading frame 10
• Synonyms
  • R33729_1
  • IL25
  • SF20
  • IL-25
  • IL-27
• GenBank acession
  • AF282264
• Locus
  19p13.3
• Discovery year
  2002-04-03
• Entrez gene record
  56005
• Pubmed identfication
  • 17362502
  • 21128247
  • 25581518
• RefSeq identity
  • NM_019107
• VEGA ID
  OTTHUMG00000182039

Gene info

• Identity
  HGNC:33091
• Gene
  SNORD116-25
• Long gene name
  small nucleolar RNA, C/D box 116-25
• Synonyms
  • HBII-85-25
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033436
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003339
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:13003
• Gene
  ZNF211
• Long gene name
  zinc finger protein 211
• Synonyms
  • ZNF-25
  • CH2H2-25
• GenBank acession
  • U38904
• Locus
  19q13.4
• Discovery year
  1999-09-29
• Pubmed identfication
  • 7633419
  • 9096115
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000168012

Gene info

• Identity
  HGNC:33013
• Gene
  SNORD114-25
• Long gene name
  small nucleolar RNA, C/D box 114-25
• Synonyms
  • 14q(II-25)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767605
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003218.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33044
• Gene
  SNORD115-25
• Long gene name
  small nucleolar RNA, C/D box 115-25
• Synonyms
  • HBII-52-25
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033801
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003342.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:49313
• Gene
  ERVW-25
• Long gene name
  endogenous retrovirus group W member 25
• Synonyms gene name
  • endogenous retrovirus group W, member 25
• GenBank acession
  • HG421063
• Locus
  13q13.3
• Discovery year
  2013-10-21

Gene info

• Identity
  HGNC:5826
• Gene
  IGKV3D-25
• Long gene name
  immunoglobulin kappa variable 3D-25 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 3D-25
  • immunoglobulin kappa variable 3D-25 pseudogene
• GenBank acession
  • X71886
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28873
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151609

Gene info

• Identity
  HGNC:54428
• Gene
  RNVU1-25
• Long gene name
  RNA, variant U1 small nuclear 25
• Locus
  1q21.1
• Discovery year
  2019-07-26
• Classification
  • Variant U1 small nuclear RNAs

Gene info

• Identity
  HGNC:5908
• Gene
  IGLV3-25
• Long gene name
  immunoglobulin lambda variable 3-25
• GenBank acession
  • X97474
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28793
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151221

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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