Recombinant Human IL7 / interleukin 7 Protein

• Catalog number
  PKSH030436-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  IL-7;Interleukin-7
• Activity
  Measured by its binding ability in a functional ELISA.Immobilized human IL7 at 10 μg/ml (100 μl/well) can bind human IL7Ra-Fch, The EC50 of human IL7Ra-Fch is 15.2-35.6 ng/ml.2. Measured in a cell proliferation assay using antibody against CD3-activated human peripheral blood lymphocytes (PBL). The ED50 for this effect is typically 1-10 ng/ml.
• Sequence
  Asp26-His177
• Fusion tag
  NA
• Accession
  NP_000871.1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  17.5 kDa
• AP Mol Mass
  19 kDa
• Formulation
  Lyophilized from sterile 25mM NaH2PO4, 400mM NaCl, pH 6.8
• Background
  IL7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Gene
  IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes. Recombinant, rec. E. coli interleukin-7 for cell culture or antibody production.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL7   interleukin   Protein  
• Gene symbol
  IL7
• Short name
  Recombinant IL7 / interleukin 7 Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens interleukin 7 / Interleukin 7 Protein
• Alternative technique
  rec
• Alternative to gene target
  interleukin 7, IL-7, IL7 and IDBG-26153 and ENSG00000104432 and 3574, growth factor activity, Extracellular, Il7 and IDBG-130583 and ENSMUSG00000040329 and 16196, IL7 and IDBG-644827 and ENSBTAG00000016284 and 280827

Gene info

• Identity
  HGNC:6023
• Gene
  IL7
• Long gene name
  interleukin 7
• Synonyms
  • IL-7
• GenBank acession
  • J04156
• Locus
  8q21.13
• Discovery year
  1989-10-12
• Entrez gene record
  3574
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000164620

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products