Recombinant Human IL1RL1 / DER4 Protein
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Catalog number
PKSH031873-50µg
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Price
Please ask
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Size
50µg
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Synonym
DER4;FIT-1;IL1RL1;IL33R;IL‑1 R4;ST2;ST2L;ST2V;T1
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Activity
NA
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Sequence
Met 1-Phe 328
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Fusion tag
NA
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Accession
NP_003847.2
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞95 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
35.6 kDa
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AP Mol Mass
55-60 kDa
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Formulation
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
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Background
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IL1RL1
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Short name
Recombinant IL1RL1 / DER4 Protein
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens interleukin 1 receptor-like 1 / DER4 Protein
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Alternative technique
rec
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Alternative to gene target
interleukin 1 receptor-like 1, DER4 and FIT-1 and IL33R and ST2 and ST2L and ST2V and T1, IL1RL1 and IDBG-64166 and ENSG00000115602 and 9173, protein binding, Extracellular, Il1rl1 and IDBG-148423 and ENSMUSG00000026069 and 17082, IL1RL1 and IDBG-630831 and ENSBTAG00000018571 and 520709
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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