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Recombinant Human IL1RL1 / DER4 Protein (Fc tag)

  • Catalog number
    PKSH031875-100µg
  • Product name
    Recombinant Human IL1RL1 / DER4 Protein (Fc tag)
  • Size
    100µg
  • Synonym
    DER4，FIT-1;IL1RL1;IL33R;IL‑1 R4;ST2;ST2L;ST2V;T1
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 / Fc Chimera with a linear range of 0.31-5 ng/ml.
  • Sequence
    Met 1-Phe 328
  • Fusion tag
    C-Fc
  • Accession
    NP_003847.2
  • Expressed Host
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    ＞95 % as determined by SDS-PAGE
  • Endotoxin
    ＜1.0 EU per µg as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    67.1 kDa
  • AP Mol Mass
    85-95 kDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
  • Technical data
    Technical_data
  • Alternative to gene target
    • [ "interleukin 1 receptor-like 1", "DER4 and FIT-1 and IL33R and ST2 and ST2L and ST2V and T1", "IL1RL1 and IDBG-64166 and ENSG00000115602 and 9173", "protein binding", "Extracellular", "Il1rl1 and IDBG-148423 and ENSMUSG00000026069 and 17082", "IL1RL1 and IDBG-630831 and ENSBTAG00000018571 and 520709" ]
  • Gene target
    IL1RL1 / DER4 Protein Fc tag
    • Gene info
  • Gene symbol
    IL1RL1
  • Short name
    Recombinant IL1RL1 / DER4 Protein (Fc tag)
  • Label
    Fc Tag
  • label filter
    • Fc Tag
  • technique filter
    • Recombinant
    • FC
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Alternative technique
    rec