Recombinant Human ESAM / Endothelial Cell Adhesion Molecule Protein 100µg

• Catalog number
  PKSH031780-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  W117m
• Activity
  NA
• Sequence
  Met 1-Ala 248
• Fusion tag
  NA
• Accession
  NP_620411.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞92 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  24.5 kDa
• AP Mol Mass
  40-45 kDa
• Formulation
  Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5
• Reconstitution
  Please refer to it for detailed information.
• Background
  Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.
• Product URL
• PDF URL
• Description
  cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the Recombinant ESAM / Endothelial Adhesion Molecule Protein 100µg. For cells, cell lines and tissues in culture till half confluency. Whole adhesion and interacting molecules are  present in lysates used as reference for ELISA quantification of these molecules and their subunits.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ESAM   Endothelial   Adhesion   Molecule   Protein   100µg  
• Gene symbol
  ESAM, ESAM-AS1
• Short name
  Recombinant ESAM / Endothelial Adhesion Molecule Protein 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens endothelial cell adhesion molecule / Endothelial cellular Adhesion Molecule Protein 100µg
• Alternative technique
  rec
• Alternative to gene target
  endothelial cell adhesion molecule, ESAM and IDBG-75276 and ENSG00000149564 and 90952, protein binding, Cell surfaces, Esam and IDBG-150411 and ENSMUSG00000001946 and 69524, BT.54007 and IDBG-642621 and ENSBTAG00000001004 and 616926
• Tissue
  cell

Gene info

• Identity
  HGNC:17474
• Gene
  ESAM
• Long gene name
  endothelial cell adhesion molecule
• Synonyms
  • W117m
• GenBank acession
  • AK075396
• Locus
  11q24.2
• Discovery year
  2003-11-26
• Entrez gene record
  90952
• Pubmed identfication
  • 11279107
  • 11906820
• RefSeq identity
  • NM_138961
• Classification
  • IgCAM CXADR-related subfamily
  • V-set domain containing
• VEGA ID
  OTTHUMG00000151986

Gene info

• Identity
  HGNC:55558
• Gene
  ESAM-AS1
• Long gene name
  ESAM antisense RNA 1
• Locus
  11q24.2
• Discovery year
  2021-04-07
• Entrez gene record
  101929340
• RefSeq identity
  • NR_120577
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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